Disease Related Glycosylation Changes and Biomarker Discovery: Challenges and Possibilities in an Emerging FieldView this Special Issue
Azita Alavi, John S. Axford, "Glyco-biomarkers: Potential Determinants of Cellular Physiology and Pathology", Disease Markers, vol. 25, Article ID 863032, 13 pages, 2008. https://doi.org/10.1155/2008/863032
Glyco-biomarkers: Potential Determinants of Cellular Physiology and Pathology
Once dismissed as just the icing on the cake, sugar molecules are emerging as vital components in life’s intricate machinery. Our understanding of their function within the context of the proteins and lipids to which they are attached has matured rapidly, and with it the far reaching clinical implications are becoming understood.Recent advances in high-throughput glycomic techniques, glyco biomarker profiling, glyco-bioinformatics and development of increasingly sophisticated glyco-arrays, combined with our increased understanding of the molecular details of glycosylation have facilitated the linkage between aberrant glycosylation and human diseases, and highlighted the possibility of using glyco-biomarkers as potential determinants of disease and its progression.The focus of this review is to give an insight into the biological significance of these glycomodifications, highlight some specific examples of glyco-biomarkers in relation to autoimmunity and in particular rheumatoid arthritis, and to explore the exciting possibility of exploiting these for diagnostic and prognostic strategies.
Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.