Disease Markers

Disease Markers / 2008 / Article

Open Access

Volume 24 |Article ID 951894 | https://doi.org/10.1155/2008/951894

Louisa Y. F. Wong, Kwok Leung Ong, Bernard M. Y. Cheung, Raymond Y. H. Leung, Yu Bun Man, Tai Hing Lam, "Polymorphisms of the Fibrinogen-Beta Gene are Related to 2-Hour Glucose Level after Oral Glucose Tolerance Test in Hong Kong Chinese", Disease Markers, vol. 24, Article ID 951894, 7 pages, 2008. https://doi.org/10.1155/2008/951894

Polymorphisms of the Fibrinogen-Beta Gene are Related to 2-Hour Glucose Level after Oral Glucose Tolerance Test in Hong Kong Chinese

Received28 Feb 2008
Accepted28 Feb 2008

Abstract

Fibrinogen, an acute phase protein, is an important inflammatory marker that is associated with cardiovascular diseases. We studied the association of three common human fibrinogen-β gene (FGB) variants, −455G>A, −249C>T, and −148C>T with glycemic parameters in 265 non-diabetic Hong Kong Chinese subjects. Both FGB variants, −455G>A and −148C>T were in complete linkage disequilibrium and were associated with higher levels of plasma fibrinogen and 2-h glucose after a 75-g oral glucose load (p <0.01). Carriers of FGB AC-haplotype, comprising the two nucleotide variants at positions −455 and −249, had higher fibrinogen level (2.64 ± 0.65 vs 2.42 ± 0.52 g/L, p = 0.002) and 2-h glucose after a 75-g oral glucose load (5.87 ± 1.14 vs 5.47 ± 1.22 g/L, p = 0.006). The associations were significant in men, but not women. In stepwise multiple regression analysis, AC-haplotype was independently associated with plasma fibrinogen level and 2-h glucose (p = 0.002 and 0.010 respectively). This suggests that fibrinogen may play a role in the development of impaired glucose tolerance.

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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