Disease Markers

Disease Markers / 2009 / Article

Open Access

Volume 27 |Article ID 529253 | https://doi.org/10.3233/DMA-2009-0643

Yingsong Lin, Kei Nakachi, Yoshinori Ito, Shogo Kikuchi, Akiko Tamakoshi, Kiyoko Yagyu, Yoshiyuki Watanabe, Yutaka Inaba, Kazuo Tajima, JACC Study Group, "Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults", Disease Markers, vol. 27, Article ID 529253, 6 pages, 2009. https://doi.org/10.3233/DMA-2009-0643

Variations in Serum Transforming Growth Factor-β1 Levels with Gender, Age and Lifestyle Factors of Healthy Japanese Adults

Received29 Sep 2009
Accepted29 Sep 2009


Elevated serum or plasma Transforming Growth Factor-β1 (TGF-β1) levels have been linked to cancer and other diseases in numerous studies; however, very few studies have reported an association between circulating TGF-β1 and lifestyle factors in healthy people. We examined the association between serum TGF-β1 levels and gender, age, body mass index (BMI), smoking, and drinking in a large population-based cohort study (N = 9,142). Serum TGF-β1 levels were detected by the Quantikine enzyme-linked immunoassay kit (R&D Systems). The data indicated highly significant (p<0.0001) difference in serum TGF-β1 levels between men (mean value: 37.6 ± 0.12 ng/mL, N = 4888) and women (mean value: 35.1 ± 0.12 ng/ml, N = 4254). Serum TGF-β1 levels decreased with age (trend p < 0.0001) and were positively associated with obesity (trend p < 0.0001) in both men and women. We observed a significant trend with increased serum TGF-β1 levels corresponding to increased amount of tobacco and alcohol consumption in men (trend p < 0.0001). These findings suggest that serum TGF-β1 levels appear to be modulated by gender, age and lifestyle factors such as obesity, cigarette smoking, and alcohol drinking in healthy Japanese adults.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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