Disease Markers

Disease Markers / 2009 / Article
Special Issue

Circulating Biomarkers in Cardiovascular Disease

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Open Access

Volume 26 |Article ID 851962 | 9 pages | https://doi.org/10.3233/DMA-2009-0646

Markers of Inflammation and Risk of Coronary Heart Disease

Received15 Sep 2009
Accepted15 Sep 2009


Cardiovascular disease is the leading cause of global mortality, with coronary heart disease (CHD) its major manifestation. Although inflammation, the body’s response to noxious stimuli, is implicated in several stages of CHD development, the relevance of circulating levels of markers of inflammation to CHD risk remains uncertain. This review summarizes available epidemiological evidence for four emerging inflammatory markers implicated in CHD (fibrinogen, C-reactive protein, lipoprotein-associated phospholipase A2 and interleukin-6); considers their likely utility in cardiovascular risk prediction; and outlines areas of outstanding uncertainty.

Copyright © 2009 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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