Disease Markers

Disease Markers / 2010 / Article
Special Issue

Combined Immunodeficiency Associated with DOCK8 Mutations and Related Immunodeficiencies

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Open Access

Volume 29 |Article ID 345436 | 8 pages | https://doi.org/10.3233/DMA-2010-0733

Epidermodysplasia Verruciformis and Susceptibility to HPV

Received14 Dec 2010
Accepted14 Dec 2010

Abstract

Purpose of review: Epidermodysplasia verruciformis has been addressed in depth in the recent literature despite its rarity. The disease is characterized by a persistence in human papillomavirus infections and development of cutaneous malignancies, usually happening more frequently and at a younger age than in the general population. Because of the role of immunodeficiency to viral antigens eventually leading to cancer, EV has become a model for understanding a viral role in cutaneous oncogenesis. Susceptibility loci for EV have been mapped and encoded protein functions are becoming better understood. Discoveries of novel mutations and further study of EV-associated HPV serotypes in lesional and nonlesional skin of affected patients and the general population may help generate a cohesive theory regarding the true role of a defective immune barrier in oncogenesis.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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