Disease Markers

Disease Markers / 2010 / Article
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Transient Environmental Agents Involved in the Cause of Primary Biliary Cirrhosis

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Volume 29 |Article ID 834926 | https://doi.org/10.3233/DMA-2010-0770

Deepti Dronamraju, Joseph Odin, Nancy Bach, "Primary Biliary Cirrhosis: Environmental Risk Factors", Disease Markers, vol. 29, Article ID 834926, 6 pages, 2010. https://doi.org/10.3233/DMA-2010-0770

Primary Biliary Cirrhosis: Environmental Risk Factors

Received24 Jan 2011
Accepted24 Jan 2011

Abstract

Primary biliary cirrhosis (PBC) is an autoimmune disease of unclear etiology. It is a chronic, progressive condition that causes intrahepatic ductal destruction ultimately leading to symptoms of cholestasis, cirrhosis and liver failure. The disease predominantly affects middle aged Caucasian women. It has a predilection to certain regions and is found in higher incidences in North America and Northern Europe. It also has a genetic predisposition with a concordance rate of 60% among monozygotic twins. Combinations of genetic and environmental factors are proposed in the pathogenesis of this disease with a compelling body of evidence that suggests a role for both these factors. This review will elucidate data on the proposed environmental agents involved the disease's pathogenesis including xenobiotic and microbial exposure and present some of the supporting epidemiologic data.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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