Disease Markers

Disease Markers / 2010 / Article

Open Access

Volume 28 |Article ID 868037 | https://doi.org/10.3233/DMA-2010-0669

Zhen-Long Zhu, Zeng-Ren Zhao, Yu Zhang, Yan-Hong Yang, Zheng-Min Wang, Dong-Sheng Cui, Ming-Wei Wang, Jörg Kleeff, Hany Kayed, Bao-Yong Yan, Xiao-Feng Sun, "Expression and Significance of FXYD-3 Protein in Gastric Adenocarcinoma", Disease Markers, vol. 28, Article ID 868037, 7 pages, 2010. https://doi.org/10.3233/DMA-2010-0669

Expression and Significance of FXYD-3 Protein in Gastric Adenocarcinoma

Received25 Mar 2010
Accepted25 Mar 2010


Objective: FXYD-3, also known as Mat-8, is a member of the FXYD protein family. It was reported that this protein can associate with and modify the transport properties of Na, K-ATPase, and may play an important role in a variety of physiological and pathological states. This protein is up-regulated in certain types of cancers (such as breast, prostate and pancreatic cancer), but down-regulated in other types of cancers (such as colon and kidney cancer). No study has been performed in gastric cancer; therefore, the aim of this project was to investigate FXYD-3 expression and its clinicopathological significance in gastric adenocarcinoma.Patients and methods: FXYD-3 protein was examined by immunohistochemistry in normal gastric mucous (n = 29) and gastric adenocarcinoma (n = 51), obtained from surgical resection of gastric cancer patients.Results: FXYD-3 protein was present in the cytoplasm of normal gastric epithelial cells or gastric cancer cells. The rate of FXYD-3 strong expression was significantly higher in cancer (51% of 51) than in normal mucosa (10% of 29, X2=13.210, p < 0.0001). FXYD-3 expressed strongly in ulcerative/infiltrating types of cancers compared to polypoid/fungating ones (X2 = 5.765, p = 0.016). However, FXYD-3 expression was not correlated with patient’s gender, age, tumor size, lymph node status and histological grade (p > 0.05).Conclosion: Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma.

Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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