Combined Immunodeficiency Associated with DOCK8 Mutations and Related ImmunodeficienciesView this Special Issue
Jeremiah C. Davis, Christopher G. Dove, Helen C. Su, "Genetic, Clinical, and Laboratory Markers for DOCK8 Immunodeficiency Syndrome", Disease Markers, vol. 29, Article ID 972591, 9 pages, 2010. https://doi.org/10.3233/DMA-2010-0737
Genetic, Clinical, and Laboratory Markers for DOCK8 Immunodeficiency Syndrome
DOCK8 immunodeficiency syndrome (DIDS) is a combined immunodeficiency characterized by recurrent viral infections, severe atopy, and early onset malignancy. Genetic studies revealed large, unique deletions in patients from different families and ethnic backgrounds. Clinical markers of DIDS include atopic dermatitis, allergies, cutaneous viral infections, recurrent respiratory tract infections, and malignancy. Immune assessments showed T cell lymphopenia, hyper-IgE, hypo-IgM, and eosinophilia. The impaired lymphocyte functions in DIDS patients appear central for disease pathogenesis.
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