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Disease Markers
Volume 30, Issue 6, Pages 275-281
http://dx.doi.org/10.3233/DMA-2011-0784

Deregulated Expression of Superoxide Dismutase-2 Correlates with Different Stages of Cervical Neoplasia

Lara Termini,1,4 Adhemar Longatto Filho,2,5 Paulo Cesar Maciag,4 Daniela Etlinger,3 Venâncio Avancini Ferreira Alves,5 Suely Nonogaki,3 Fernando Augusto Soares,6,7 and Luisa Lina Villa1,4

1Ludwig Institute for Cancer Research – Hospital Alemão Oswaldo Cruz, São Paulo (SP), Brazil
2Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Campus de Gualtar, Braga, Portugal
3Pathology Division, Adolfo Lutz Institute, São Paulo (SP), Brazil
4HPV Institute – INCT-HPV, Santa Casa de Misericórdia, São Paulo (SP), Brazil
5Laboratory of Medical Investigation (LIM) 14, Department of Pathology, University of São Paulo, School of Medicine, São Paulo(SP), Brazil
6Department of Anatomic Pathology, Hospital do A. C. Camargo, São Paulo (SP), Brazil
7Department of General Pathology, Faculty of Dentistry of the University of São Paulo, São Paulo, Brazil

Received 28 June 2011; Accepted 28 June 2011

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective: Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme may be involved in carcinogenesis, particularly in lung, gastric, colorectal and breast cancer.

Methods: In the present study, we have evaluated SOD2 protein levels by immunohistochemistry (IHC) in 331 cervical histological samples including 31 low-grade cervical intraepithelial neoplasia (LSIL), 51 high-grade cervical intraepithelial neoplasia (HSIL), 197 squamous cervical carcinomas (SCC) and 52 cervical adenocarcinomas (ADENO).

Results: We observed that SOD2 staining increases with cervical disease severity. Intense SOD2 staining was found in 13% of LSIL, 25.5% of HSIL and 40% of SCC. Moreover, 65.4% of ADENO exhibited intense SOD2 staining.

Conclusions: Differences in the expression of SOD2 could potentially be used as a biomarker for the characterization of different stages of cervical disease.