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Disease Markers
Volume 30 (2011), Issue 5, Pages 229-233
http://dx.doi.org/10.3233/DMA-2011-0779

Mcl-1 Expression Is Up-Regulated in Malignancies of the Parotid Gland

Gregor Heiduschka,1 Boban M. Erovic,1 Johannes Pammer,2 Ulana Kotowski,1 Alexandra Kaider,3 Matthaeus Ch. Grasl,1 and Dietmar Thurnher1

1Department of Otorhinolaryngology, Head and Neck Surgery, Comprehensive Cancer Center, Medical University of Vienna, Austria
2Department of Otorhinolaryngology, Pathology, Comprehensive Cancer Center, Medical University of Vienna, Austria
3Department of Otorhinolaryngology, Medical Computer Sciences, Comprehensive Cancer Center, Medical University of Vienna, Austria

Received 28 June 2011; Accepted 28 June 2011

Copyright © 2011 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The anti-apoptotic protein Mcl-1 is highly expressed in various types of malignant tumors. Overexpression is reported to correlate with poor prognosis and disease progression. We report the expression levels of Mcl-1 in tumor samples of the parotid gland. A retrospective study containing 108 patients was performed. A tissue microarray of six malignancies of the parotid gland and pleomorphic adenoma as control was constructed. Parotid gland tumor samples were immunohistochemically stained for Mcl-1 and expression intensities were assessed. Statistical analysis included correlation to patients' clinical data and comparison of malignancies to the adenoma.

All malignancies had significantly higher expression of Mcl-1 than the pleomorphic adenomas. The intensity, however, had no significant correlation to overall survival.

Our immunohistochemical findings indicate that parotid gland malignancies produce high levels of Mcl-1 protein. Therefore, Mcl-1 might serve as a predictive co-marker in tumors of the parotid gland.