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Disease Markers
Volume 32, Issue 6, Pages 337-342
http://dx.doi.org/10.3233/DMA-2012-0896

Limited Value of KAI1/CD82 Protein Expression as a Prognostic Marker in Human Gastric Cancer

Maximilian Knoener, Till Krech, Florian Puls, Ulrich Lehmann, Hans Kreipe, and Matthias Christgen

Institute of Pathology, Hannover Medical School, Hannover, Germany

Received 8 March 2012; Accepted 8 March 2012

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The cell surface glycoprotein KAI1/CD82 suppresses tumor growth and metastasis in animal models. This study aimed to evaluate the prognostic relevance of KAI1/CD82 protein expression in human gastric cancer. Primary gastric carcinomas (n = 271) with amean clinical follow-up time of 48months were immunostained using the monoclonal anti-KAI1/CD82 antibody G2. Staining was evaluated as negative versus positive for statistical analysis. KAI1/CD82 immunoreactivity was absent in 103/271 (38%) cases. There was a trend towards KAI1/CD82 negativity in poorly differentiated cases (p = 0.0679). Moreover, KAI1/CD82-negative carcinomas were associated with a higher pT status (p = 0.0222), metastatic lymph node involvement (p = 0.0018) and a higher clinical tumor stage (p = 0.0050). The median overall survival times of KAI1/CD82-negative and KAI1/CD82-positive gastric carcinomas were 20 and 37 months, respectively (p = 0.2305). These results are in line with the proposed function of KAI1/CD82 as a suppressor of tumor growth and metastasis. However, these data suggest that KAI1/CD82, as detected by immunohistochemistry, is of limited value as a prognostic marker for gastric cancer in routine histological workup.