Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 33, Issue 4, Pages 171-178
http://dx.doi.org/10.3233/DMA-2012-0930

PINCH Expression and Its Clinicopathological Significance in Gastric Adenocarcinoma

Zhen-Long Zhu,1,2 Bao-Yong Yan,3 Yu Zhang,4 Yan-Hong Yang,1 Zheng-Min Wang,1 Hong-Zhen Zhang,3 Ming-Wei Wang,3 Xiang-Hong Zhang,2 and Xiao-Feng Sun5

1Department of Pathology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
2Graduate School of Hebei Medical University, Shijiazhuang, Hebei, China
3Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China
4Clinical College of Hebei Medical University, Shijiazhuang, Hebei, China
5Division of Oncology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, University of Linköping, Country Council of Östergötland, Linköping, Sweden

Received 11 September 2012; Accepted 11 September 2012

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Objective: Particularly interesting new cysteine-histidine rich protein (PINCH) is an important component of the local adhesion complexes and upregulated in several types of malignancies, and involved in the incidence and development of tumours. PINCH expression is also independently correlated with poorer survival in patients with colorectal cancer. However, there is no study of PINCH in gastric cancer, therefore, the aim of this project was to investigate PINCH expression and its clinicopathological significance in gastric adenocarcinoma.

Patients and methods: PINCH expression was immunohistochemically examined in normal gastric mucous (n = 30) and gastric adenocarcinoma (n = 73), from gastric cancer patients.

Results: PINCH expression in the associated-stroma of gastric cancers was heterogeneous, and its positive rate (75%) was higher than that of normal gastric mucosa (43%, X2 = 9.711, p = 0.002). The stronger staining was observed at the invasive edge of tumour when compared to the inner area of tumour. The rate of positive PINCH (88%) in the cases with lymph node metastasis was higher than that (52%) in the cases without metastasis (X2 = 11.151, p = 0.001). PINCH expression was not correlated with patients’ gender, age, tumour size, differentiation and invasion depth (p > 0.05).

Comclusion: PINCH protein might play an important role in the tumourigenesis and metastasis of gastric adenocarcinoma.