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Disease Markers
Volume 32, Issue 4, Pages 231-239
http://dx.doi.org/10.3233/DMA-2011-0879

Replication of Relevant SNPs Associated with Cardiovascular Disease Susceptibility Obtained from GWAs in a Case-Control Study in a Canarian Population

Francisco Rodríguez Esparragón,1,2 Osmel Companioni,1 Miguel García Bello,1 Nisa Buset Ríos,1 and José Carlos Rodríguez Pérez1,2,3

1Unidad de Investigación, HIRICARE Study Group, Hospital Universitario de Gran Canaria, Las Palmas de Gran Canaria, Gran Canaria, Spain
2Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Gran Canaria, Spain
3Servicio de Nefrología, Hospital Universitario de Gran Canaria, Las Palmas de Gran Canaria, Gran Canaria, Spain

Received 15 March 2012; Accepted 15 March 2012

Copyright © 2012 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recent genome-wide single nucleotide polymorphism (SNP) association studies (GWAS) have identified a number of SNPs that were significantly associated with coronary artery disease (CAD) and myocardial infarction (MI). We tested for replication of the previously described association with CAD in our case-control datasets of SNPs variants located at 1p13.1, 2q33.1, 10q11.1, 9p21, and 21q22. We observed a small significant risk associated of the SNP rs10757274 with CAD in the PROCAGENE study. Besides, the multilocus combination rs10757274 and rs1333048 gave a near significant result. We confirmed that the SNP rs10757274 showed association with CAD in the PROCAGENE study, although after applying the Bonferroni correction was not longer significant. Independent replication studies in other populations are needed to unequivocally confirm the association.