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Disease Markers
Volume 35 (2013), Issue 4, Pages 243–247
http://dx.doi.org/10.1155/2013/107470
Research Article

Association of IL-4-590 C>T and IL-13-1112 C>T Gene Polymorphisms with the Susceptibility to Type 2 Diabetes Mellitus

1Genetics Unit, Children Hospital, Mansoura University, Egypt
2Zoology Department, Faculty of Science, Mansoura University, Egypt
3Diabetes and Endocrinology Unit, Specialized Medicine Hospital, Mansoura University, Egypt
4College of Medicine, Qassim University, P.O. Box 5566, Buraydah 51432, Saudi Arabia

Received 18 June 2013; Revised 5 August 2013; Accepted 17 August 2013

Academic Editor: Xiaohong Li

Copyright © 2013 Afaf Alsaid et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. A. Doria, M.-E. Patti, and C. R. Kahn, “The emerging genetic architecture of type 2 diabetes,” Cell Metabolism, vol. 8, no. 3, pp. 186–200, 2008. View at Publisher · View at Google Scholar · View at Scopus
  2. D. Voehringer, T. A. Reese, X. Huang, K. Shinkai, and R. M. Locksley, “Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system,” Journal of Experimental Medicine, vol. 203, no. 6, pp. 1435–1446, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Ueta, C. Sotozono, T. Inatomi, K. Kojima, J. Hamuro, and S. Kinoshita, “Association of combined IL-13/IL-4R signaling pathway gene polymorphism with stevens-johnson syndrome accompanied by ocular surface complications,” Investigative Ophthalmology and Visual Science, vol. 49, no. 5, pp. 1809–1813, 2007. View at Google Scholar
  4. M. Ueta, C. Sotozono, T. Inatomi, K. Kojima, J. Hamuro, and S. Kinoshita, “Association of combined IL-13/IL-4R signaling pathway gene polymorphism with stevens-johnson syndrome accompanied by ocular surface complications,” Investigative Ophthalmology and Visual Science, vol. 495, no. 5, pp. 1809–1813, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. S. Daneshmandi, A. Pourfathollah, M. K. Arababadi, G. Hassanshahi, M. Rezaeian, and M. Asiabanha, “Evaluation of relation between IL-4 and IFN-γ polymorphisms and type 2 diabetes,” Journal of Mazandaran University of Medical Sciences, vol. 18, 2008. View at Google Scholar
  6. T. D. Howard, P. A. Whittaker, A. L. Zaiman et al., “Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a dutch population,” American Journal of Respiratory Cell and Molecular Biology, vol. 25, no. 3, pp. 377–384, 2001. View at Google Scholar · View at Scopus
  7. K. J. Stanya, D. Jacobi, and S. Liu, “Direct control of hepatic glucose production by interleukin-13 in mice,” Journal of Clinical Investigation, vol. 123, no. 1, pp. 261–271, 2013. View at Google Scholar
  8. L. M. Maier, J. Chapman, J. M. M. Howson et al., “No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes,” American Journal of Human Genetics, vol. 76, no. 3, pp. 517–521, 2005. View at Publisher · View at Google Scholar · View at Scopus
  9. K. G. Alberti and P. Z. Zimmet, “Definition, diagnosis and classification of diabetes mellitus and its complications—part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation,” Diabetic Medicine, vol. 15, pp. 539–553, 1998. View at Google Scholar
  10. W. M. Howell, S. J. Turner, J. M. Theaker, and A. C. Bateman, “Cytokine gene single nucleotide polymorphisms and susceptibility to and prognosis in cutaneous malignant melanoma,” European Journal of Immunogenetics, vol. 30, no. 6, pp. 409–414, 2003. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Hummelshoj, U. Bodtger, P. Datta et al., “Association between an interleukin-13 promoter polymorphism and atopy,” European Journal of Immunogenetics, vol. 30, no. 5, pp. 355–359, 2003. View at Publisher · View at Google Scholar · View at Scopus
  12. P. Skopiński, E. Rogala, B. Duda-Król et al., “Increased interleukin-18 content and angiogenic activity of sera from diabetic (Type 2) patients with background retinopathy,” Journal of Diabetes and Its Complications, vol. 19, no. 6, pp. 335–338, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. R. Nosratabadi, M. K. Arababadi, G. Hassanshahi et al., “Evaluation of IFN-γ serum level in nephropatic type 2 diabetic patients,” Pakistan Journal of Biological Sciences, vol. 12, no. 9, pp. 746–749, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. K.-T. Ho, M.-Y. Shiau, Y.-H. Chang, C.-M. Chen, S.-C. Yang, and C.-N. Huang, “Association of interleukin-4 promoter polymorphisms in Taiwanese patients with type 2 diabetes mellitus,” Metabolism, vol. 59, no. 12, pp. 1717–1722, 2010. View at Publisher · View at Google Scholar · View at Scopus
  15. H. Bid, R. Konwar, C. Agrawal, and M. Banerjee, “Association of IL-4 and IL-1RN (receptor antagonist) gene variants and the risk of type 2 diabetes mellitus: a study in the north Indian population,” Indian Journal of Medical Sciences, vol. 62, no. 7, pp. 259–266, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. M. K. Arababadi, A. A. Pourfathollah, S. Daneshmandi et al., “Evaluation of relation between IL-4 and IFN-γ polymorphisms and type 2 diabetes,” Iranian Journal of Basic Medical Sciences, vol. 12, no. 2, pp. 100–104, 2009. View at Google Scholar
  17. M. C. Calle and M. L. Fernandez, “Inflammation and type 2 diabetes,” Diabetes and Metabolism, vol. 38, no. 3, pp. 183–191, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Cui, J. Jia, C.-F. Ma et al., “IL-13 polymorphisms contribute to the risk of asthma: a meta-analysis,” Clinical Biochemistry, vol. 45, no. 4-5, pp. 285–288, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. H.-B. Kim, Y.-C. Lee, S.-Y. Lee et al., “Gene-gene interaction between IL-13 and IL-13Rα1 is associated with total IgE in Korean children with atopic asthma,” Journal of Human Genetics, vol. 51, no. 12, pp. 1055–1062, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Ryba-Stanisławowska, M. Skrzypkowska, M. Myśliwiec, and J. Myśliwska, “Loss of the balance between CD4+Foxp3+ regulatory T cells and CD4+IL17A+ Th17 cells in patients with type 1 diabetes,” Human Immunology, vol. 74, no. 6, pp. 701–707, 2013. View at Google Scholar
  21. K. Imam, “Clinical features, diagnostic criteria and pathogenesis of diabetes mellitus,” Advances in Experimental Medicine and Biology, vol. 771, pp. 340–355, 2012. View at Google Scholar
  22. D. La Torre, “Immunobiology of beta-cell destruction,” Advances in Experimental Medicine and Biology, vol. 771, pp. 194–218, 2012. View at Google Scholar