Early Complication in Sickle Cell Anemia Children due to A(TA)_nTAA Polymorphism at the Promoter of UGT1A1 Gene

Table 1

Hematological, demographic, and clinical data of studied population.

	Normal values		SCA patients with; cholelithiasis	SCA patients without; cholelithiasis	Patients with; cholelithiasis	𝑃1	𝑃2
	M	F
Number			52 SS	50 SS	76 AA
Age (mean)			13±2.9	10±3.6	35±5	0.425	0.020
Sex ratio (M/F)			24/28	20/30	33/43	0.423	0.323
Hb (g/dL)	13–18	12–16	7.3±0.9	7.9±1.3	13±0.15	0.521	0.035
RBC (1012/L)	4.5–6.2	4–5.4	2.89±1.02	3.29±0.9	4.80±0.7	0.270	0.120
MCV (fL)	80–100	80–100	77.2±1.3	79.7±0.9	85±2	0.560	0.049
MCH (pg)	27–32	27–32	35.7±1.02	34.9±2.1	30.2±1.03	0.100	0.130
RDW (%)	11–14	11–14	5.29±1.02	4.83±0.5	13.2±0.2	0.579	0.029
HbA (%)	97-98	97-98	0	0	97±0.2	1	0.012
HbS (%)	0	0	86.4±0.4	86±0.3	0	1	0.012
HbF (%)	0	0	10.6±0.3	11±0.1	0	1	0.012
HbA2 (%)	2-3	2-3	3±0.1	3±0.2	3±0.2	1	0.012
Total bilirubin level (𝜇mol/L)	<17	<17	80.25	53.5	30.3	0.001	0.020
Unconjugated bilirubin level (𝜇mol/L)	<14	<14	70.12	38.2	25.8	0.001	0.035
Conjugated bilirubin level (𝜇mol/L)	<14	<14	10.13	15.3	4.5	0.001	0.120

Usual value of total bilirubin level is <17 𝜇mol/L.
SS: homozygous of 𝛽-globin gene mutation.
AA: normal adult hemoglobin.
The demographic and hematologic values are indicated as mean ± standard deviation.
The bilirubin values are indicated as medians.
Hb: hemoglobin, RBC: red blood cell, MCV: mean corpuscular volume, MCH: mean corpuscular hemoglobin, and RDW: red blood distribution width.
Statistics for the comparison of demographic and hematological variables between the two groups were performed using the 𝑡-test and chi-square test as appropriate (SPSS 18.0).
Statistics for the comparison of bilirubin level between the two groups were performed using the nonparametric Mann-Whitney test (SPSS 18.0).
𝑃: index of significance, each 𝑃<0.05 is considered as significant. 𝑃1: comparison between SCA patients according to the presence or the absence of cholelithiasis. 𝑃2: comparison between SCA patients without cholelithiasis and patients with cholelithiasis.