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Disease Markers
Volume 35 (2013), Issue 5, Pages 567–572
Research Article

Tissue Kidney Injury Molecule-1 Expression in the Prediction of Renal Function for Several Years after Kidney Biopsy

1Clinic of Nephrology, Clinical Center of Serbia, Pasterova 2, 11 000 Belgrade, Serbia
2School of Medicine, University of Belgrade, Serbia
3Clinical Hospital Center Bezanijska Kosa, Belgrade, Serbia
4Institute of Pathology, School of Medicine, University of Belgrade, Belgrade, Serbia
5Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia

Received 30 June 2013; Accepted 7 October 2013

Academic Editor: Giuseppe Murdaca

Copyright © 2013 Sanja Simic Ogrizovic et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. Retrospective study was designed to examine the importance of tissue kidney injury molecule-1 (KIM-1) expression in predicting kidney function in sixty patients (27 males) aged 34.15 ± 12.23 years with different kidney diseases over three years after kidney biopsy. Materials and Methods. Tissue KIM-1 expression was determined immunohistochemically and KIM-1 staining was scored semiquantitatively, as well as tubulointerstitialis (TIN), inflammation, atrophy, and fibrosis. Kidney function (MDRD formula) and proteinuria/day were evaluated at the time of biopsy (GFR0) and 6, 12, 24, and 36 months later. Results. Significantly positive correlations between tissue KIM-1 expression and age ( ), TIN inflammation ( ), fibrosis ( ), and proteinuria at 6 months ( ) as well as negative correlations with GFR0 ( ), GFR6 ( ), GFR24 ( ), and GFR36 ( ) were found. Meanwhile, TIN inflammation was the best predictor of all measured kidney functions during three years, while tissue KIM-1 expression ( ) was a predictor only at 6 months after biopsy. Conclusion. Tissue KIM-1 expression significantly predicts kidney function solely at 6 months after biopsy, when the effects of immune and nonimmune treatments are the strongest.