HLA Markers for Poor Prognosis in Systemic Sclerosis Brazilian Patients

Table 3

Frequency of class II HLA alleles in pulmonary fibrosis (PF) and pulmonary arterial hypertension (PAH).

HLA	PF			PAH
	+; 𝑁 (%)	−; 𝑁 (%)	𝑃	+; 𝑁 (%)	−; 𝑁 (%)	𝑃
	61	80		19	122
DRB1*01	5 (8.2)	22 (27.5)	0.004	4 (21.0)	23 (18.9)	0.761
DRB1*04	14 (22.9)	18 (22.5)	0.950	5 (26.3)	27 (22.1)	0.769
DRB1*16	3 (4.9)	8 (10.0)	0.350	0 (0)	11 (9.0)	0.360
DRB1*11	24 (39.3)	23 (28.7)	0.186	7 (36.8)	40 (32.8)	0.727
DRB1*10	1 (1.6)	6 (7.5)	NC	0 (0)	7 (5.7)	0.594
DRB1*13	10 (16.4)	13 (16.2)	0.086	5 (26.3)	28 (22.9)	0.773
DRB1*08	10 (16.4)	6 (7.5)	0.099	3 (15.8)	13 (10.7)	0.454
DRB1*15	14 (22.9)	16 (20.0)	0.671	3 (15.8)	27 (22.1)	0.764
DRB1*03	14 (22.9)	17 (21.2)	0.809	4 (21.0)	27 (22.1)	1
DRB1*07	9 (14.7)	12 (15.0)	0.968	1 (5.3)	20 (16.4)	0.307
DRB1*09	3 (4.9)	1 (1.2)	NC	1 (5.3)	3 (2.6)	NC
DRB1*12	3 (4.9)	1 (1.2)	NC	1 (5.3)	3 (2.6)	NC
DRB1*14	2 (3.3)	1 (1.2)	NC	0 (0)	3 (2.6)	NC
DRB5	13 (21.3)	18 (22.5)	0.866	2 (10.6)	29 (23.8)	0.246
DRB5*01	4 (6.6)	3 (3.7)	NC	1 (5.3)	6 (4.9)	1
DRB3	11 (18.0)	10 (12.5)	0.361	2 (10.6)	19 (15.6)	0.739
DRB3*01	2 (3.3)	7 (8.7)	0.299	0 (0)	9 (7.4)	0.690
DRB3*02	28 (46.0)	36 (45.0)	0.915	10 (52.6)	54 (44.3)	0.496
DRB4	3 (4.9)	0	NC	1 (5.3)	2 (1.6)	NC
DRB4*01	22 (36.0)	31 (38.7)	0.744	5 (26.3)	48 (39.3)	0.275
DQB1*03	34 (55.8)	44 (55.0)	0.930	11 (57.9)	67 (55.0)	0.808
DQB1*05	11 (18.0)	38 (47.5)	<0.001	4 (21.0)	45 (36.9)	0.178
DQB1*06	23 (37.7)	32 (40.0)	0.782	7 (36.8)	48 (39.3)	0.835
DQB1*02	19 (31.1)	24 (30.0)	0883	4 (21.0)	39 (31.9)	0.336
DQB1*04	14 (22.9)	7 (8.7)	0.019	5 (26.3)	16 (13.1)	0.163

NC: Non calculable.