Association of TAP Gene Polymorphisms and Risk of Cervical Intraepithelial Neoplasia
Table 3
Genotype and allele frequencies of the five investigated TAP gene polymorphisms in women with cervical intraepithelial neoplasia (CIN) and controls.
Gene polymorphisms
Controls (%)
CIN (%)
OR (95% CI)
TAP 1341
0.08
1.4 (1.0-2.0)
wt/wt
155 (75.2%)
423 (68.7%)
wt/mt
44 (21.4%)
172 (27.9%)
mt/mt
7 (3.4%)
21 (3.4%)
TAP 2254
0.3
1.3 (0.9–1.8)
wt/wt
161 (78.2%)
455 (73.9%)
wt/mt
39 (18.9%)
148 (24.0%)
mt/mt
6 (2.9%)
12 (1.9%)
TAP 1135
0.8
0.9 (0.7–1.3)
wt/wt
143 (69.4%)
435 (70.6%)
wt/mt
51 (24.8%)
165 (26.8%)
mt/mt
12 (5.8%)
16 (2.6%)
TAP 1693
0.3
1.3 (0.8–2.2)
wt/wt
184 (89.3%)
531 (86.2%)
wt/mt
22 (10.7%)
84 (13.6%)
mt/mt
0 (0%)
1 (0.2%)
TAP 1993
0.2
0.8 (0.6–1.1)
wt/wt
90 (43.7%)
301 (48.9%)
wt/mt
92 (44.7%)
248 (40.3%)
mt/mt
24 (11.7%)
66 (10.7%)
Statistical analysis by chi-square test are calculated wt/wt versus wt/mt and mt/mt. TAP: transporter associated with antigen processing. CIN: cervical intraepithelial neoplasia. OR (95% CI): odds ratio (95% confidence interval).
