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Disease Markers
Volume 35, Issue 6, Pages 799–805
Clinical Study

Rather than Rs1800796 Polymorphism, Expression of Interleukin-6 Is Associated with Disease Progression of Chronic HBV Infection in a Chinese Han Population

1Department of General Surgery, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan 430071, China
2Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan 430071, China
3State Key Laboratory of Virology, Institute of Virology, Medical School of Wuhan University, Wuhan 430071, China

Received 14 August 2013; Revised 30 October 2013; Accepted 4 November 2013

Academic Editor: Francisco Blanco-Vaca

Copyright © 2013 Shengli Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Interleukin-6 plays an important role in chronic inflammation as well as tumor growth and progression. Here, a case-control study was undertaken to investigate the association of rs1800796 polymorphism of IL-6 gene and serum levels with disease progression of chronic HBV infection. Rs1800796 polymorphism was genotyped in 641 Chinese Han patients with chronic HBV infection, including 23 IT, 25 IC, 292 CHB, 153 LC, and 148 HCC patients and 265 healthy controls. Serum IL-6 levels were measured in 23 IT, 25 IC, 47 CHB, 41 LC, and 49 HCC patients and 45 healthy controls, and the classifications of HCC were accorded to BCLC staging system. We found no significant association between rs1800796 polymorphism and disease progression of chronic HBV infection; however, serum IL-6 levels showed significant statistical differences between patients with CHB, LC, and HCC. Moreover, statistical differences can be observed in patients with terminal stage HCC compared with those of early to intermediate or advanced stage HCC. Our findings suggest that rs1800796 polymorphism unlikely contribute significantly to affect the progression of chronic HBV infection, and serum IL-6 levels can act as a useful indicator for disease progression and severity of chronic HBV infection.