A Semiautomated Framework for Integrating Expert Knowledge into Disease Marker Identification

Figure 2

The bar graph of the average fold changes of the protein abundances in diseased group relative to their controls of four potential biomarkers identified in mouse BALF. The positive fold changes indicate the observed upregulation in the diseased group, the Ada −/− mice, and the negative fold changes indicate the observed downregulation. The significances of these changes are indicated with two (𝑃  value is between 0.01 and 0.001), one (𝑃  value is between 0.01 and 0.05), or no asterisk (𝑃  value is greater than 0.05). The arrow in dashed line of ADIPO shows that this protein was present in the BALF of the Ada −/− mice but absent in the Ada +/− group. The mouse data from the last two time points (on days 38 and 42) were used for this analysis.