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Disease Markers
Volume 34, Issue 1, Pages 33-39
http://dx.doi.org/10.3233/DMA-2012-120945

Psoriasin: A Novel Marker Linked Obesity with Psoriasis

Ragaa H. M. Salama,1 Hani A. Al-Shobaili,2 Ahmad A. Al Robaee,2 and Abdullateef A. Alzolibani2

1Department of Medical Biochemistry, College of Medicine, Qassim University, Qassim, KSA
2Department of Dermatology, College of Medicine, Qassim University, Qassim, KSA

Received 12 November 2012; Accepted 12 November 2012

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

To evaluate the role of psoriasin, koebnerisin, interleukn (IL)-12 and IL-23 in the pathogenesis of psoriasis and their relations to Psoriasis Area Severity Index (PASI) and obesity. Thirty patients had chronic plaque psoriasis and 30 healthy subjects matched in age and sex were enrolled in this study. Serum from all subjects were used for determination of psoriasin, koebnerisin, IL-12 and IL-23 by ELISA kits. IL-23 and psoriasin were significantly higher in skin psoriasis compared to controls and psoriatic arthritis (PsA). There was a correlation between psoriasin and both PASI and obesity. On the other hand, IL-12 was significantly increased in PsA compared to skin psoriasis (p = 0.000) and controls. Its sensitivity and specificity were 87%, 93%; respectively. To our knowledge, psoriasin is the first biomarker confirm the link between obesity and psoriasis. The risk of developing psoriasis is directly related to higher BMI.