Association between Angiotensin II Type 1 Receptor Polymorphism and Sudden Cardiac Death in Myocardial Infarction

Table 4

Association between AT1R A/C polymorphism and ACS risk factors.

ATR1 genotypes	AA (𝑛=241); n	AC (𝑛=329); n	Univariate	P	CC (𝑛=179); n	Univariate	P
ACS risk factors			OR (95% CI)			OR (95% CI)
UAP	145	214	1.37 (0.31–2.18)	0.273	66	1.24 (0.73–2.98)	0.148
AMI	96	115	1.21 (0.51–2.834)	0.670	113	3.35 (1.11–0.12)	0.032
Age (mean)	65.7±11.1	61.2±13.5	0.98 (0.95–1.01)	0.232	60.3±14.1	0.97 (0.94–1.01)	0.149
Sex—male	137	146	1.35 (0.43–7.54)	0.450	149	1.18 (0.38–3.72)	0.776
Hypertension	131	143	0.57 (0.23–1.44)	0.236	103	0.40 (0.14–1.21)	0.104
Diabetes mellitus	117	137	0.88 (0.36–2.16)	0.780	75	1.36 (0.43–4.33)	0.603
Hypercholesterolemia	54	107	0.63 (0.21–1.87)	0.403	52	0.92 (0.23–3.68)	0.905
BMI (kg/m^2) ≥ 27	17	26	2.16 (0.65–9.33)	0.151	13	1.67 (0.22–9.73)	0.622
Systolic blood pressure ≥ 140 mmHg	109	131	0.50 (0.20–1.25)	0.137	87	1.13 (0.39–3.24)	0.822
Diastolic blood pressure ≥ 90 mmHg	28	40	0.36 (0.12–1.10)	0.143	26	1.18 (0.38–3.72)	0.776
Heart failure history	21	32	0.88 (0.31–2.51)	0.817	16	1.59 (0.49–5.18)	0.445
CAD history	143	204	1.67 (0.37–2.07)	0.755	107	0.95 (0.17–3.62)	0.257
MI history	36	42	1.23 (0.28–5.51)	0.785	27	1.08 (0.17–7.00)	0.936
Family history of ACS	12	17	0.35 (0.03–4.01)	0.399	9	0.80 (0.07–9.30)	0.855
Family history of diabetes	21	33	0.47 (0.07–2.03)	0.576	17	0.97 (0.25–2.46)	0.767
Smoking	105	136	0.89 (0.38–2.09)	0.793	87	1.28 (0.45–3.64)	0.639

UAP: unstable angina pectoris, AMI: acute myocardial infarction, BMI: Body mass index, and CAD: coronary artery disease.