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Disease Markers
Volume 35, Issue 3, Pages 195–202
Research Article

Overexpression of FXYD-3 Is Involved in the Tumorigenesis and Development of Esophageal Squamous Cell Carcinoma

1Department of Pathology, The First Hospital of Hebei Medical University, Shijiazhuang 050031, China
2Graduate School of Hebei Medical University, Shijiazhuang 050017, China
3Central Laboratory, The First Hospital of Hebei Medical University, Shijiazhuang 050031, China
4Clinical College of Hebei Medical University, Shijiazhuang 050031, China
5Applied Tumor Virology, University of Heidelberg, Heidelberg, Germany
6Division of Oncology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Country Council of Östergötland, University of Linköping, 581 85 Linköping, Sweden

Received 2 January 2013; Revised 13 June 2013; Accepted 16 July 2013

Academic Editor: Yuk Ming Dennis Lo

Copyright © 2013 Zhen-Long Zhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. To investigate the association of FXYD-3 expression with clinicopathological variables and PINCH in patients with ESCC. Patients and Methods. Expression of FXYD-3 protein was immunohistochemically examined in normal esophageal mucous ( ) and ESCC ( ). Results. Expression of FXYD-3 in the cytoplasm markedly increased from normal esophageal epithelial cells to primary ESCC ( ). The expression of FXYD-3 was correlated with TNM stages and depth of tumor invasion. Furthermore, the cases with lymph node metastasis tended to show a higher frequency of positive expression than those without metastasis ( ), and FXYD-3 expression tended to be positively related to the expression of PINCH ( ). Moreover, the cases positive for both proteins had the highest frequency of lymph node metastasis ( ). However, FXYD-3 expression was not correlated with patient’s gender ( ), age ( ), tumor location ( ), size ( ), grade of differentiation ( ), and survival ( ). Conclusion. Overexpression of FXYD-3 in the cytoplasm may play an important role in the tumorigenesis and development in the human ESCC, particularly in combination with PINCH expression.