Overexpression of FXYD-3 Is Involved in the Tumorigenesis and Development of Esophageal Squamous Cell Carcinoma

Table 1

The relationship of FXYD-3 protein expression with clinicopathological and biological variables in the patients with ESCC.

Variables	𝑁	FXYD-3 expression		𝜒^2	𝑃 value
		Negative (%)	Positive (%)
Gender
Male	50	20 (40)	30 (60)	0.037	0.847
Female	14	6 (43)	8 (57)
Age (years)
≤50	19	8 (42)	11 (58)	0.025	0.876
>50	45	18 (40)	27 (60)
Tumour location
Upper	7	3 (43)	4 (57)	2.556	0.279
Middle	36	14 (39)	22 (61)
Lower	21	9 (43)	12 (57)
Tumour size (cm)
≤3	26	10 (38)	16 (62)	0.085	0.771
>3	38	16 (42)	22 (58)
Lymph node status
Nonmetastasis	44	21 (48)	23 (52)	2.944	0.086
Metastasis	20	5 (25)	15 (75)
Grade of differentiation
I	20	11 (55)	9 (45)	2.556	0.279
II	39	13 (33)	26 (67)
III	5	2 (40)	3 (60)
Depth of invasion
Mucosa and submucosa	14	9 (64)	5 (36)	4.159	0.041
Muscularis and adventitia	50	17 (34)	33 (66)
TNM stage
I	14	10 (71)	4 (29)	7.049	0.008
II+III+IV	50	16 (32)	34 (68)
Survival (years)
≥5	11	8 (73)	3 (27)	2.508	0.113
<5	27	12 (44)	15 (56)
PINCH
Negative	28	15 (54)	13 (46)	3.459	0.063
Positive	36	11 (31)	25 (69)

ESCC: esophageal squamous cell carcinoma.
PINCH: particularly interesting new cysteine-histidine rich protein.