Coding and Noncoding Gene Expression Biomarkers in Mood Disorders and Schizophrenia

Table 2

There were 22 transcripts with statistically significant treatment response × probeset interaction effects on expression after FDR step-up correction. The Affymetrix transcript ID, gene symbol, nominal 𝑃 values, FDR step-up 𝑃 value, and means for each group and largest probeset fold change (FC) are shown in the table. Fold change was calculated as 2^{(responder − nonresponder)}.

Transcript ID	Gene symbol	TR × probeset P value	TR × probeset Step-up P value	Mean nonresp.	Mean resp.	FC
3034987	ADAP1	1.96×10^−14	4.24×10^−10	1	0.86	1.3527
3062794	TECPR1	3.59×10^−08	3.19×10^−04	0.69	0.7	1.13796
2566848	AFF3	4.44×10^−08	3.19×10^−04	−0.09	0.08	−1.52384
3812922	NETO1	4.08×10^−07	2.20×10^−03	−0.16	0.03	−1.58384
3521372	DZIP1	5.94×10^−07	2.56×10^−03	−0.32	−0.46	1.44937
3224650	DENND1A	1.40×10^−06	5.04×10^−03	0.77	0.69	1.70799
3933131	C21orf129	1.73×10^−06	5.23×10^−03	−0.1	−0.09	−1.45665
3044283	CRHR2	1.94×10^−06	5.23×10^−03	0.12	0.12	1.54165
2525989	CPS1	2.29×10^−06	5.48×10^−03	−0.43	−0.28	−1.30682
3601229	CD276	3.33×10^−06	7.18×10^−03	0.46	0.35	1.42523
2773958	CXCL10	4.17×10^−06	8.18×10^−03	−0.56	−0.31	−1.54359
2317317	TP73	4.78×10^−06	8.59×10^−03	1.14	1.02	1.24552
3901296	CST3	5.63×10^−06	9.34×10^−03	0.93	0.83	1.31194
3956781	AP1B1	1.33×10^−05	0.02	1.45	1.37	1.19835
3638760	IDH2	1.46×10^−05	0.021	1.45	1.37	1.28415
3494137	LMO7	1.99×10^−05	0.026	0.33	0.48	−1.53258
2450798	LAD1	2.01×10^−05	0.026	0.57	0.51	1.2701
3724858	TBX21	2.22×10^−05	0.027	0.95	0.76	1.38771
3376433	SLC22A25	2.46×10^−05	0.028	−0.58	−0.58	−1.16635
2676182	NT5DC2	2.79×10^−05	0.03	1.13	1.03	1.29257
2930418	UST	4.01×10^−05	0.041	0.24	0.58	−1.56098
3821847	ASNA1	4.74×10^−05	0.046	1.48	1.43	1.32183

TR: treatment response; resp.: responder; nonresp.: nonresponder.