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Disease Markers
Volume 35, Issue 6, Pages 701–710
http://dx.doi.org/10.1155/2013/762685
Research Article

Investigation of Genetic Polymorphisms Related to the Outcome of Radiotherapy for Prostate Cancer Patients

1Programa de Mestrado em Genética, Pontifícia Universidade Católica de Goiás, Avenida Universitária 1440 Setor Universitário, 74605-010 Goiânia, GO, Brazil
2Laboratório de Oncogenética e Radiobiologia, Associação de Combate ao Câncer em Goiás, Rua 239 N.52 Lt.29, Setor Universitário, 74605-070 Goiânia, GO, Brazil
3Departamento de Medicina, Pontifícia Universidade Católica de Goiás, Avenida Universitária 1440 Setor Universitário, 74605-010 Goiânia, GO, Brazil
4Serviço de Radioterapia, Hospital Araújo Jorge, Associação de Combate ao Câncer em Goiás, Rua 239 N.52 Lt.181, Setor Universitário, 74605-070 Goiânia GO, Brazil

Received 30 June 2013; Accepted 8 October 2013

Academic Editor: Esperanza Ortega

Copyright © 2013 Hellen Silva Cintra et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. G. C. Barnett, C. M. L. West, A. M. Dunning et al., “Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype,” Nature Reviews Cancer, vol. 9, no. 2, pp. 134–142, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. N. G. Burnet, R. M. Elliott, A. Dunning, and C. M. L. West, “Radiosensitivity, Radiogenomics and RAPPER,” Clinical Oncology, vol. 18, no. 7, pp. 525–528, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. C. M. L. West, A. M. Dunning, and B. S. Rosenstein, “Genome-wide association studies and prediction of normal tissue toxicity,” Seminars in Radiation Oncology, vol. 22, no. 2, pp. 91–99, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. J. A. Cesaretti, R. G. Stock, S. Lehrer et al., “ATM sequence variants are predictive of adverse radiotherapy response among patients treated for prostate cancer,” International Journal of Radiation Oncology Biology Physics, vol. 61, no. 1, pp. 196–202, 2005. View at Publisher · View at Google Scholar · View at Scopus
  5. J. A. Cesaretti, R. G. Stock, D. P. Atencio et al., “A genetically determined dose-volume histogram predicts for rectal bleeding among patients treated with prostate brachytherapy,” International Journal of Radiation Oncology Biology Physics, vol. 68, no. 5, pp. 1410–1416, 2007. View at Publisher · View at Google Scholar · View at Scopus
  6. C. A. Peters, R. G. Stock, J. A. Cesaretti et al., “TGFB1 single nucleotide polymorphisms are associated with adverse quality of life in prostate cancer patients treated with radiotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 70, no. 3, pp. 752–759, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. R. J. Burri, R. G. Stock, J. A. Cesaretti et al., “Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer,” Radiation Research, vol. 170, no. 1, pp. 49–59, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. S. L. Kerns, H. Ostrer, R. Stock et al., “Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer,” International Journal of Radiation Oncology Biology Physics, vol. 78, no. 5, pp. 1292–1300, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. G. Iliakis, “The role of DNA double strand breaks in ionizing radiation-induced killing of eukaryotic cells,” BioEssays, vol. 13, no. 12, pp. 641–648, 1991. View at Google Scholar · View at Scopus
  10. F. Altieri, C. Grillo, M. Maceroni, and S. Chichiarelli, “DNA damage and repair: from molecular mechanisms to health implications,” Antioxidants and Redox Signaling, vol. 10, no. 5, pp. 891–937, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. A. J. Levine and M. Oren, “The first 30 years of p53: growing ever more complex,” Nature Reviews Cancer, vol. 9, no. 10, pp. 749–758, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. M. B. Kastan and D.-S. Lim, “The many substrates and functions of ATM,” Nature Reviews Molecular Cell Biology, vol. 1, no. 3, pp. 179–186, 2000. View at Google Scholar · View at Scopus
  13. A. Tichý, J. Vávrová, J. Pejchal, and M. Rezácová, “Ataxia-telangiectasia mutated kinase (ATM) as a central regulator of radiation-induced DNA damage response,” Acta Medica, vol. 53, no. 1, pp. 13–17, 2010. View at Google Scholar · View at Scopus
  14. T. Soussi and K. G. Wiman, “Shaping genetic alterations in human cancer: the p53 mutation paradigm,” Cancer Cell, vol. 12, no. 4, pp. 303–312, 2007. View at Publisher · View at Google Scholar · View at Scopus
  15. Y. Levav-Cohen, S. Haupt, and Y. Haupt, “Mdm2 in growth signaling and cancer,” Growth Factors, vol. 23, no. 3, pp. 183–192, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. P. Dumont, J. I.-J. Leu, A. C. Della Pietra III, D. L. George, and M. Murphy, “The codon 72 polymorphic variants of p53 have markedly different apoptotic potential,” Nature Genetics, vol. 33, no. 3, pp. 357–365, 2003. View at Publisher · View at Google Scholar · View at Scopus
  17. D. D. Ørsted, S. E. Bojesen, A. Tybjærg-Hansen, and B. G. Nordestgaard, “Tumor suppressor p53 Arg72Pro polymorphism and longevity, cancer survival, and risk of cancer in the general population,” Journal of Experimental Medicine, vol. 204, no. 6, pp. 1295–1301, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. X. Li, P. Dumont, A. Della Pietra, G. Shetler, and M. E. Murphy, “The codon 47 polymorphism in p53 is functionally significant,” Journal of Biological Chemistry, vol. 280, no. 25, pp. 24245–24251, 2005. View at Publisher · View at Google Scholar · View at Scopus
  19. X.-L. Tan, O. Popanda, C. B. Ambrosone et al., “Association between TP53 and p21 genetic polymorphisms and acute side effects of radiotherapy in breast cancer patients,” Breast Cancer Research and Treatment, vol. 97, no. 3, pp. 255–262, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. G. L. Bond, W. Hu, E. E. Bond et al., “A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans,” Cell, vol. 119, no. 5, pp. 591–602, 2004. View at Publisher · View at Google Scholar · View at Scopus
  21. A. Y. Ho, G. Fan, D. P. Atencio et al., “Possession of ATM sequence variants as predictor for late normal tissue responses in breast cancer patients treated with radiotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 69, no. 3, pp. 677–684, 2007. View at Publisher · View at Google Scholar · View at Scopus
  22. C. E. Canman, D.-S. Lim, K. A. Cimprich et al., “Activation of the ATM kinase by ionizing radiation and phosphorylation of p53,” Science, vol. 281, no. 5383, pp. 1677–1679, 1998. View at Publisher · View at Google Scholar · View at Scopus
  23. J. D. Cox, J. Stetz, and T. F. Pajak, “Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC),” International Journal of Radiation Oncology Biology Physics, vol. 31, no. 5, pp. 1341–1346, 1995. View at Publisher · View at Google Scholar · View at Scopus
  24. C. N. Andreassen, J. Alsner, and J. Overgaard, “Does variability in normal tissue reactions after radiotherapy have a genetic basis—where and how to look for it?” Radiotherapy and Oncology, vol. 64, no. 2, pp. 131–140, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. S. Angèle, P. Romestaing, N. Moullan et al., “ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity,” Cancer Research, vol. 63, no. 24, pp. 8717–8725, 2003. View at Google Scholar · View at Scopus
  26. C. N. Andreassen, J. Overgaard, J. Alsner et al., “ATM sequence variants and risk of radiation-induced subcutaneous fibrosis after postmastectomy radiotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 64, no. 3, pp. 776–783, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. S. Damaraju, D. Murray, J. Dufour et al., “Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer,” Clinical Cancer Research, vol. 12, no. 8, pp. 2545–2554, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. G. L. Bond, W. Hu, and A. Levine, “A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect,” Cancer Research, vol. 65, no. 13, pp. 5481–5484, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. S. L. Harris, G. Gil, H. Robins et al., “Detection of functional single-nucleotide polymorphisms that affect apoptosis,” Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 45, pp. 16297–16302, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. O. Popanda, J. U. Marquardt, J. Chang-Claude, and P. Schmezer, “Genetic variation in normal tissue toxicity induced by ionizing radiation,” Mutation Research, vol. 667, no. 1-2, pp. 58–69, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. J. J. Jaboin, M. Hwang, C. A. Perez et al., “No evidence for association of the MDM2-309 T/G promoter polymorphism with prostate cancer outcomes,” Urologic Oncology, vol. 29, no. 3, pp. 319–323, 2011. View at Publisher · View at Google Scholar · View at Scopus
  32. L. Sreeja, V. Syamala, P. B. Raveendran, S. Santhi, J. Madhavan, and R. Ankathil, “p53 Arg72Pro polymorphism predicts survival outcome in lung cancer patients in Indian population,” Cancer Investigation, vol. 26, no. 1, pp. 41–46, 2008. View at Publisher · View at Google Scholar · View at Scopus
  33. M. B. Parliament and D. Murray, “Single nucleotide polymorphisms of DNA repair genes as predictors of radioresponse,” Seminars in Radiation Oncology, vol. 20, no. 4, pp. 232–240, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. T. Pugh, M. Keyes, L. Barclay et al., “Sequence variant discovery in DNA repair genes from radiosensitive and radiotolerant prostate brachytherapy patients,” Clinical Cancer Research, vol. 15, no. 15, pp. 5008–5016, 2009. View at Publisher · View at Google Scholar · View at Scopus
  35. M. Yang, L. Zhang, N. Bi et al., “Association of P53 and ATM polymorphisms with risk of radiation-induced pneumonitis in lung cancer patients treated with radiotherapy,” International Journal of Radiation Oncology Biology Physics, vol. 79, no. 5, pp. 1402–1407, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Alsbeih, N. Al-Harbi, M. Al-Buhairi, K. Al-Hadyan, and M. Al-Hamed, “Association between TP53 codon 72 single-nucleotide polymorphism and radiation sensitivity of human fibroblasts,” Radiation Research, vol. 167, no. 5, pp. 535–540, 2007. View at Publisher · View at Google Scholar · View at Scopus
  37. M. C. Zody, M. Garber, D. J. Adams et al., “DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage,” Nature, vol. 440, no. 7087, pp. 1045–1049, 2006. View at Publisher · View at Google Scholar · View at Scopus
  38. H. I. Suzuki, K. Yamagata, K. Sugimoto, T. Iwamoto, S. Kato, and K. Miyazono, “Modulation of microRNA processing by p53,” Nature, vol. 460, no. 7254, pp. 529–533, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. A. K. L. Leung and P. A. Sharp, “microRNAs: a safeguard against turmoil?” Cell, vol. 130, no. 4, pp. 581–585, 2007. View at Publisher · View at Google Scholar · View at Scopus
  40. Z. Peng, Y. Cheng, B. C.-M. Tan et al., “Comprehensive analysis of RNA-Seq data reveals extensive RNA editing in a human transcriptome,” Nature Biotechnology, vol. 30, no. 3, pp. 253–260, 2012. View at Publisher · View at Google Scholar · View at Scopus
  41. F. Gemignani, V. Moreno, S. Landi et al., “A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA,” Oncogene, vol. 23, no. 10, pp. 1954–1956, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. V. Lazar, F. Hazard, F. Bertin, N. Janin, D. Bellet, and B. Bressac, “Simple sequence repeat polymorphism within the p53 gene,” Oncogene, vol. 8, no. 6, pp. 1703–1705, 1993. View at Google Scholar · View at Scopus
  43. C. West, B. S. Rosenstein, and J. Alsner, “Establishment of a radiogenomics consortium,” International Journal of Radiation Oncology, Biology, Physics, vol. 76, no. 5, pp. 1295–1296, 2010. View at Google Scholar