Investigation of Genetic Polymorphisms Related to the Outcome of Radiotherapy for Prostate Cancer Patients
Table 6
Association of the polymorphisms analysed with acute skin, gastrointestinal, and urinary radiation toxicity.
Acute skin RTOG
Acute Gastrointestinal RTOG
Acute Urinary Tract RTOG
Gene (refSNP)
Genotype
n (%)
HG
LG
OR
95% CI
P value
HG
LG
OR
95% CI
P value
HG
LG
OR
95% CI
P value
ATM
GG
36 (75)
1
35
5
31
17
19
(rs1801516)
12 (25)
1
11
0.314
0.018–5.452
0.441
2
10
0.806
0.135–4.821
1
6
6
0.895
0.242–3.307
1
TP53
GG
25 (52)
2
23
4
21
12
13
(rs1042522)
GC
17 (35)
0
17
3.723
0.168–82.615
0.506
2
15
1.429
0.231–8.840
1
9
8
0.820
0.239–2.819
1
CC
6 (13)
0
6
1.383
0.059–32.563
1
1
5
0.952
0.086–10.489
1
2
4
1.846
0.284–11.983
0.664
TP53
CC
45 (96)
2
43
6
39
22
23
(rs1800371)
CT†
2 (4)
0
2
0.287
0.011–7.744
1
1
1
6.500
0.357–118.37
0.278
0
2
4.787
0.217–105.39
0.491
TP53
CC
43 (91)
2
41
5
38
19
24
(rs17883323)
4 (9)
0
4
0.542
0.022–13.157
1
2
2
0.132
0.015–1.153
0.100
3
1
0.264
0.025–2.745
0.328
TP53
CC
41 (89)
0
41
6
35
18
23
(rs35117667)
CT
2 (4)
0
2
—
—
‡
0
2
0.915
0.039–21.368
1
1
1
0.783
0.046–13.399
1
TT
3 (7)
2
1
0.007
0.0002–0.227
0.003
1
2
2.917
0.227–37.425
0.413
2
1
2.556
0.214–30.469
0.583
TP53
A1
40 (87)
2
38
6
34
20
20
(rs17878362)
A2
6 (13)
0
6
0.844
0.036–19.676
1
1
5
1.133
0.112–11.484
1
2
4
0.500
0.082–3.046
0.667
MDM2
TT
18 (38)
1
17
1
17
9
9
(rs2279744)
GT
27 (56)
1
26
1.529
0.089–26.136
1
6
21
0.206
0.023–1.880
0.215
12
15
1.250
0.378–4.133
0.767
GG
3 (6)
0
3
0.600
0.02–17.996
1
0
3
0.600
0.020–17.996
1
2
1
0.500
0.038–6.547
1
Abbreviations: refSNP: reference SNP cluster report; RTOG: radiation therapy oncology group; HG: high grade RTOG; LG: low grade RTOG; OR: odds ratio; CI: confidence interval. To make calculations of Fishers exact test possible, when one value is zero, 0.5 was added to the value. No carriers of an AA homozygous genotype were found. No carriers of a TT homozygous genotype were found. No patient high grade for the genotypes analysed.
