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Disease Markers
Volume 35 (2013), Issue 6, Pages 641–646
Research Article

Association of Functional VKORC1 Promoter Polymorphism with Occurrence and Clinical Aspects of Ischemic Stroke in a Greek Population

1Laboratory of Pharmacology, Medical School, Democritus University of Thrace, Dragana Campus, 68100 Alexandroupolis, Greece
2Department of Neurology, University of Patras, Rion, 26500 Patras, Greece

Received 30 June 2013; Revised 25 September 2013; Accepted 9 October 2013

Academic Editor: Ralf Lichtinghagen

Copyright © 2013 Georgia Ragia et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Genetic factors are considered to play an important role in determining the susceptibility to the occurrence, clinical course, and functional outcome of an acute ischemic stroke (IS). Undercarboxylation of specific vitamin K-dependent proteins, due to genetic polymorphisms of VKORC1, can affect both vascular calcification and thrombogenicity. We sought to determine the association of VKORC11639G > A polymorphism with IS incidence, age of onset, severity of disease, and functional outcome after an acute IS. VKORC11639G > A polymorphism was determined in 145 consecutive patients with first ever IS and 145 age- and sex-matched control subjects of Greek Caucasian origin using PCR-RFLP. Stroke severity and functional outcome were assessed on admission and at one month after stroke, respectively. Frequency of VKORC11639G > A genotypes did not differ between IS patients and controls ( , ). Moreover, carriage of the A allele was not associated with age of stroke onset, severity of disease (Scandinavian stroke scale score 32.2 versus 32.9, resp., ), or poor outcome at 1 month post-stroke (52.9 versus 64.4%, resp., ). In conclusion, VKORC11639G > A polymorphism is not a genetic determinant of IS occurrence, age of onset, severity, or functional outcome of disease in a Greek population.