Detection of Urinary Metabolomics before and after Pringle Maneuver-Induced Liver Ischemia and Reperfusion Injury in Rats Using Gas Chromatography-Mass Spectrometry

Figure 1

Hematoxylin and eosin staining results by group. S1 and S2, sham group; A1 and A2, day 1 group; B1 and B2, day 3 group; C1 and C2, day 5 group. In the sham group, the liver sinusoids were normal, and no congestion was found (0 point). S1 and S2 indicate cord-like arrangement of liver cells, no obvious liver cell necrosis, and a very small amount of vacuolization. A1 and A2 show a small amount of congestion in the hepatic sinusoids, moderate amount of vacuolization, darkly stained and pyknotic nuclei of the liver cells, lightly stained cytoplasm, and swollen liver cells compressing the expanded hepatic sinusoids. B1 and B2 show that the injury was alleviated; the liver sinusoids were dilated, and some vacuoles were observed, which were surrounded by more normal liver cells. C1 and C2 show normal liver sinusoidal expansion, cord-like liver cell arrangement, basically normal liver cells, and no obvious congestion.