Research Article
Involvement of Fibroblast Growth Factor Receptor Genes in Benign Prostate Hyperplasia in a Korean Population
Table 2
Frequencies of the genotypes and alleles of polymorphisms of FGFR genes in BPH patients and control subjects.
| | Gene | SNP | Genotype/allele | Control | BPH | Models | OR (95% CI) | | | (%) | (%) |
| | FGFR1 | rs13317 | T/T | 85 (39.9) | 83 (35.6) | Additive | 1.11 (0.83–1.47) | 0.48 | | T/C | 100 (47.0) | 116 (49.8) | Dominant | 1.16 (0.79–1.72) | 0.45 | | C/C | 28 (13.2) | 34 (14.6) | Recessive | 1.09 (0.63–1.90) | 0.75 | | T | 270 (63.4) | 282 (60.5) | | 1 | | | C | 156 (36.6) | 184 (39.5) | | 1.13 (0.86–1.48) | 0.38 |
| | FGFR2 | rs755793 | T/T | 193 (90.6) | 208 (89.3) | Additive | 1.08 (0.59–2.00) | 0.80 | | T/C | 20 (9.4) | 24 (10.3) | Dominant | 1.04 (0.55–1.96) | 0.90 | | C/C | 0 (0.0) | 1 (0.4) | Recessive | NA (0.00-NA) | NA | | T | 406 (95.3) | 440 (94.4) | | 1 | | | C | 20 (4.7) | 26 (5.6) | | 1.20 (0.66–2.18) | 0.55 | | rs1047100 | G/G | 193 (90.6) | 196 (84.1) | Additive | 1.92 (1.07–3.43) | 0.024 | | G/A | 20 (9.4) | 35 (15.0) | Dominant | 1.89 (1.04–3.45) | 0.034 | | A/A | 0 (0.0) | 2 (0.9) | Recessive | NA (0.00-NA) | NA | | G | 406 (95.3) | 427 (91.6) | | 1 | | | A | 20 (4.7) | 39 (8.4) | | 1.85 (1.06–3.23) | 0.029 | | rs3135831 | C/C | 92 (43.2) | 116 (49.8) | Additive | 0.83 (0.63–1.09) | 0.17 | | C/T | 88 (41.3) | 90 (38.6) | Dominant | 0.80 (0.55–1.18) | 0.26 | | T/T | 33 (15.5) | 27 (11.6) | Recessive | 0.72 (0.41–1.25) | 0.24 | | C | 272 (63.8) | 322 (69.1) | | 1 | | | T | 154 (36.2) | 144 (30.9) | | 0.79 (0.60–1.04) | 0.10 |
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