Research Article
Involvement of Fibroblast Growth Factor Receptor Genes in Benign Prostate Hyperplasia in a Korean Population
Table 3
Frequencies of the genotypes and alleles of polymorphisms of FGFR genes, based on small and large prostate volume, in subjects with BPH.
| | Gene | SNP | Genotype/allele | Prostate volume (mL) | Models | OR (95% CI) | | <30
(%) | ≥30
(%) |
| | FGFR1 | rs13317 | T/T | 36 (33.6) | 46 (36.8) | Additive | 1.03 (0.69–1.52) | 0.89 | | T/C | 58 (54.2) | 58 (46.4) | Dominant | 0.88 (0.50–1.53) | 0.64 | | C/C | 13 (12.2) | 21 (16.8) | Recessive | 1.41 (0.66–3.01) | 0.38 | | T | 130 (60.7) | 150 (60.0) | | 1 | | | C | 84 (39.3) | 100 (40.0) | | 1.03 (0.71–1.50) | 0.87 |
| | FGFR2 | rs755793 | T/T | 93 (86.9) | 114 (91.2) | Additive | 0.54 (0.24–1.21) | 0.13 | | T/C | 13 (12.2) | 11 (8.8) | Dominant | 0.55 (0.23–1.30) | 0.17 | | C/C | 1 (0.9) | 0 (0.0) | Recessive | 0.00 (0.00-NA) | NA | | T | 199 (93.0) | 239 (95.6) | | 1 | | | C | 15 (7.0) | 11 (4.4) | | 0.61 (0.27–1.36) | 0.23 | | rs1047100 | G/G | 83 (77.6) | 112 (89.6) | Additive | 0.43 (0.21–0.87) | 0.016 | | G/A | 23 (21.5) | 12 (9.6) | Dominant | 0.38 (0.18–0.81) | 0.010 | | A/A | 1 (0.9) | 1 (0.8) | Recessive | 0.70 (0.04–11.33) | 0.80 | | G | 189 (88.3) | 236 (94.4) | | 1 | | | A | 25 (11.7) | 14 (5.6) | | 0.45 (0.23–0.89) | 0.021 | | rs3135831 | C/C | 50 (46.7) | 65 (52) | Additive | 0.92 (0.63–1.36) | 0.68 | | C/T | 44 (41.1) | 46 (36.8) | Dominant | 0.88 (0.52–1.49) | 0.62 | | T/T | 13 (12.2) | 14 (11.2) | Recessive | 0.96 (0.42–2.17) | 0.91 | | C | 144 (67.3) | 176 (70.4) | | 1 | | | T | 70 (32.7) | 74 (29.6) | | 0.87 (0.58–1.28) | 0.47 |
|
|
Bold characters represent statistically significant values ().
|
