Involvement of Fibroblast Growth Factor Receptor Genes in Benign Prostate Hyperplasia in a Korean Population

Table 4

Frequencies of the genotypes and alleles of polymorphisms of FGFR genes, based on low and high international prostate symptom score (IPSS), in subjects with BPH.

Gene	SNP	Genotype/allele	IPSS		Models	OR (95% CI)	𝑃
			<20; 𝑛=130 (%)	≥20; 𝑛=76 (%)
FGFR1	rs13317	T/T	37 (28.5)	36 (47.4)	Additive	0.50 (0.32–0.79)	0.0022
		T/C	71 (54.6)	34 (44.7)	Dominant	0.43 (0.23–0.78)	0.005
		C/C	22 (16.9)	6 (7.9)	Recessive	0.40 (0.15–1.03)	0.044
		T	145 (55.8)	106 (69.7)		1
		C	115 (44.2)	46 (30.3)		0.55 (0.36–0.84)	0.005
FGFR2	rs755793	T/T	113 (86.9)	70 (92.1)	Additive	0.53 (0.20–1.37)	0.17
		T/C	16 (12.3)	6 (7.9)	Dominant	0.54 (0.20–1.44)	0.20
		C/C	1 (0.8)	0 (0)	Recessive	0.00 (0.00-NA)	NA
		T	242 (93.1)	146 (96.1)		1
		C	18 (6.9)	6 (3.9)		0.55 (0.21–1.42)	0.22
	rs1047100	G/G	107 (82.3)	67 (88.2)	Additive	0.60 (0.27–1.32)	0.19
		G/A	21 (16.1)	9 (11.8)	Dominant	0.63 (0.27–1.45)	0.27
		A/A	2 (1.5)	0 (0)	Recessive	0.00 (0.00-NA)	NA
		G	235 (90.4)	143 (94.1)		1
		A	25 (9.6)	9 (5.9)		0.59 (0.27–1.30)	0.19
	rs3135831	C/C	65 (50)	36 (47.4)	Additive	0.91 (0.60–1.39)	0.67
		C/T	46 (35.4)	35 (46)	Dominant	1.17 (0.66–2.07)	0.60
		T/T	19 (14.6)	5 (6.6)	Recessive	0.41 (0.15–1.15)	0.07
		C	176 (67.7)	107 (70.4)		1
		T	84 (32.3)	45 (29.6)		0.88 (0.57–1.36)	0.57

Bold characters represent statistically significant values (𝑃<0.05/4).