ESR1 rs9340799 Is Associated with Endometriosis-Related Infertility and In Vitro Fertilization Failure

Table 2

Genotype and allele frequencies of TP53 signaling pathway gene polymorphisms.

	Fertile 𝑛 (%)	Endometriosis 𝑛 (%)	𝑃 value*	IVF Failure 𝑛 (%)	𝑃 value**
MDM2; rs2279744
TT	57 (42.5)	41 (41.8)	0.824	48 (41.7)	0.918
TG	64 (47.8)	45 (45.9)		54 (47)
GG	13 (9.7)	12 (12.2)		13 (11.3)
G	0.67	0.65	0.765	0.65	0.765
T	0.33	0.35		0.35
MDM4; rs1563828
CC	34 (25.4)	34 (34.7)	0.268	40 (34.8)	0.141
CT	71 (53)	43 (42.9)		59 (51.3)
TT	29 (21.6)	21 (21.4)		16 (13.9)
C	0.52	0.57	0.477	0.6	0.254
T	0.48	0.43		0.4
HAUSP; rs1529916
CC	73 (54.5)	53 (54.1)	0.977	53 (46.1)	0.224
CT	52 (38.8)	39 (39.8)		48 (41.7)
TT	9 (6.7)	6 (6.1)		14 (12.2)
C	0.74	0.74	1	0.67	0.277
T	0.26	0.26		0.33
LIF; rs929271
TT	57 (42.5)	47 (48)	0.702	46 (40)	0.784
TG	60 (44.8)	39 (39.8)		51 (44.3)
GG	17 (12.7)	12 (12.2)		18 (15.7)
T	0.65	0.68	0.653	0.62	0.659
G	0.35	0.32		0.38
ESR1; rs9340799
AA	71 (53)	27 (27.6)	<0.001	45 (39.1)	0.018
AG	54 (40.3)	55 (56.1)		51 (44.3)
GG	9 (6.7)	16 (16.3)		19 (16.5)
A	0.73	0.55	0.008	0.61	0.071
G	0.27	0.45		0.39
ESR1; rs2234693
CC	27 (20.1)	18 (18.4)	0.861	17 (14.8)	0.105
CT	69 (51.5)	54 (55.1)		51 (44.3)
TT	38 (28.4)	26 (26.5)		47 (40.9)
C	0.46	0.46	1	0.37	0.196
T	0.54	0.54		0.63

∗Chi-square analysis for the difference between Fertile and Endometriosis groups. ∗∗Chi-square analysis for the difference between Fertile and IVF Failure groups.