Disease Markers

Disease Markers / 2013 / Article

Open Access

Volume 34 |Article ID 798914 | https://doi.org/10.3233/DMA-2012-00936

Lorenz Kuessel, Christoph Grimm, Martin Knöfler, Peter Haslinger, Heinz Leipold, Georg Heinze, Christian Egarter, Maximilian Schmid, "Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth", Disease Markers, vol. 34, Article ID 798914, 6 pages, 2013. https://doi.org/10.3233/DMA-2012-00936

Common Oxytocin Receptor Gene Polymorphisms and the Risk for Preterm Birth

Received22 Oct 2012
Accepted22 Oct 2012

Abstract

Oxytocin is crucially involved in the onset and maintenance of labor. We investigated the association between oxytocin receptor gene polymorphisms and preterm birth. The presence of four common oxytocin receptor gene polymorphisms (rs2254298, rs53576, rs2228485 and rs237911) was evaluated in one hundred women with preterm birth and one hundred healthy women using restriction fragment length polymorphism genotyping. No association was found between the presence of any individual oxytocin receptor gene polymorphism and preterm birth. In haplotype analysis, the haplotype combination of rs2254298 A allele, rs2228485 C allele and rs237911 G allele was found to be significantly associated with an increased risk of preterm birth (OR = 3.2 [CI 1.04–9.8], p = 0.043). In conclusion our findings suggest that a combination of three oxytocin receptor gene polymorphisms is associated with an increased risk for preterm birth. We propose further studies investigating the role of oxytocin receptor gene polymorphisms and preterm birth.

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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