Reduced Paraoxonase 1 Activity as a Marker for Severe Coronary Artery Disease

Table 1

Plasma PON1 activity and biochemical index in apoE^−/− mice with different ages.

Parameters	3 months; (𝑛=8)	6 months; (𝑛=8)	12 months; (𝑛=7)	18 months; (𝑛=6)
TC (mmol/L)	13.34±1.24	13.73±1.03	14.74±0.90^∗#	15.64±0.79^∗∗#
Triglycerides (mmol/L)	1.91±0.38	1.95±0.41	1.63±0.18	1.72±0.20
TNF-α (pg/mL)	74.1±21.4	124.4±24.8^∗∗	150.9±23.9^∗∗	177.3±10.0^∗∗##▵
IL-6 (pg/mL)	92.3±11.8	114.0±14.7^∗	111.0±22.8	154.9±17.9^∗∗##▵▵
PON1 activity (U/mL)	121.9±8.1	108.6±8.2^∗	96.6±13.2^∗∗#	80.6±6.7^∗∗##▵

Data are given as mean ± SD. ^∗𝑃<0.05, ^∗∗𝑃<0.01, compared with 3 m group; ^#𝑃<0.05, ^##𝑃<0.01, compared with 6 m group; ^▵𝑃<0.05, ^▵▵𝑃<0.01, compared with 12 m group.