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Disease Markers
Volume 34 (2013), Issue 6, Pages 379-386
http://dx.doi.org/10.3233/DMA-130984

Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

Jing He,2 Fengmei Zhang,2 Ying Wu,2 Wei Zhang,2 Xiaoli Zhu,3 Xuelian He,4 Yuhang Zhao,5 Wei Zhang,2 and Yulan Zhao1

1School of Life Science, East China Normal University, Shanghai, China
2Institutes for Advanced Interdisciplinary Research, East China Normal University, Shanghai, China
3Department of Otorhinolaryngology, Peking Union Medical College Hospital, Beijing, China
4Central Laboratory, Wuhan Children's Hospital, Wuhan, Hubei, China
5Shanghai Integrated Circuit Research and Development Center, Shanghai, China

Received 5 March 2013; Accepted 5 March 2013

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

BACKGROUND: Recent studies have shown that microRNAs (miRNA) have prognostic values in cancers. This meta-analysis seeks to summarize the global predicting role of miR-155 for survival in patients with a variety of carcinomas.

METHODS: Eligible studies were identified through multiple search strategies. Data were extracted from studies investigating the relationship between miR-155 expression and survival in cancer patients. Combined hazard ratios (HRs) of miR-155 for outcome were analyzed.

RESULTS: A total of 16 studies dealing with various carcinomas were included for this meta-analysis. For overall survival, higher miR-155 expression could significantly predict worse outcome with the pooled HR of 2.057 (95% CI: 1.392–3.039). For relapse or progress-free survival, elevated miR-155 was also a significant predictor, with a combined HR of 1.918 (95% CI: 1.311–2.806,). In addition, subgroup analysis showed that higher expression of miR-155 had the trends to predict worse outcome in lung cancer. However, the HRs did not reach the statistical significance.

CONCLUSION: Our findings suggest that miR-155 detection has a prognostic value in cancer patients. Regularly measuring miR-155 expression may be useful in clinical practice.