Combined Analysis of Serum Alpha-Fetoprotein and MAGE-A3-Specific Cytotoxic T Lymphocytes in Peripheral Blood for Diagnosis of Hepatocellular Carcinoma
Figure 1
(a) Frequency of MAGE-A3-specific cytotoxic T lymphocytes (CTLs). The percentages of CD8+MAGE-A3+ CTLs in CD8+ T-cell populations from HCC patients (), liver cirrhosis patients (), and healthy controls (). The results shown are representative of at least three independent experiments; . (b) Histograms of the frequency of MAGE-A3+ CTLs in the HCC group, liver cirrhosis group, and healthy controls. Box bars show the differences in frequency among the three groups (one-way ANOVA, ). The data are presented in two groups: the cancer group, and non-cancer control group (independent t-test, ). . (c) MAGE-A3 mRNA expression in hepatocellular carcinoma (HCC) and adjacent non-cancerous tissues and testis tissues. GAPDH was used as internal control. M: 100 bp ladder marker; T: tumor; N: adjacent tissue; Tes: testis tissue.
