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Disease Markers
Volume 35, Issue 2, Pages 105–112
http://dx.doi.org/10.1155/2013/913715
Research Article

Relationship between Acute Phase Proteins and Serum Fatty Acid Composition in Morbidly Obese Patients

1Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Trindade Campus, 88040-900 Florianópolis, SC, Brazil
2Graduate Program in Nutrition Center, Federal University of Santa Catarina, Trindade Campus, 88040-900 Florianópolis, SC, Brazil
3Department of Physiology, Biological Sciences Building, Centro Politécnico Campus, Federal University of Paraná, Avenida Cel Francisco H dos Santos, s/n, 81530-900 Jardim das Américas, PR, Brazil
4Physiological Sciences Department, Biological Sciences Center, Federal University of Santa Catarina, Trindade Campus, 88040-900 Florianópolis, SC, Brazil
5Department of Nutrition and Post-Graduate Program in Nutrition, Federal University of Santa Catarina, Trindade Campus, 88040-900 Florianópolis, SC, Brazil

Received 31 January 2013; Accepted 1 May 2013

Academic Editor: Sudhir Srivastava

Copyright © 2013 Ricardo Fernandes et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Obesity is considered a low-grade inflammatory state and has been associated with increased acute phase proteins as well as changes in serum fatty acids. Few studies have assessed associations between acute phase proteins and serum fatty acids in morbidly obese patients. Objective. To investigate the relationship between acute phase proteins (C-Reactive Protein, Orosomucoid, and Albumin) and serum fatty acids in morbidly obese patients. Methods. Twenty-two morbidly obese patients were enrolled in this study. Biochemical and clinical data were obtained before bariatric surgery, and fatty acids measured in preoperative serum. Results. Orosomucoid was negatively correlated with lauric acid ( ) and eicosapentaenoic acid (EPA) ( ) and positively with arachidonic acid (AA) ( ), AA/EPA ratio ( ), and n-6/n-3 polyunsaturated fatty acids ratio ( ). C-Reactive Protein (CRP) was negatively correlated with lauric acid ( ), and both CRP and CRP/Albumin ratio were negatively correlated with margaric acid ( , , resp.). Albumin was positively correlated with EPA ( ) and margaric acid ( ). Other correlations were not statistically significant. Conclusion. Our findings suggest that serum fatty acids are linked to acute phase proteins in morbidly obese patients.