Inflammatory Cytokines and the Risk of Cardiovascular Complications in Type 2 Diabetes

Table 4

Pearson product-moment analysis of correlations between lymphocyte expression of intracellular cytokines and CD4+CD25+FOXP3+ cells in All type 2 diabetes patients (T2DM), CHD-afflicted T2DM, and in healthy control subjects.

	IFN-Υ	TNF-𝛼	IL-8	IL-6	IL-1𝛽
All T2DM
CD4+IL-17+ cells	𝑟=−0.173	𝑟=−0.072	𝑟=0.309^∗	𝑟=0.256	𝑟=0.358^∗
CD4+CD25+FOXP3+ cells	𝑟=−0.096	𝑟=−0.189	𝑟=0.143	𝑟=0.276^∗	𝑟=0.308^∗
CD4+CD25+FOXP3+/Th1 cells	𝑟=−0.333^∗∗	𝑟=−0.234	𝑟=0.249	𝑟=−0.188	𝑟=0.186
T2DM with CHD
CD4+IL-17+ cells	𝑟=0.362	𝑟=0.189	𝑟=0.699	𝑟=0.706	𝑟=0.842^∗
CD4+CD25+FOXP3+ cells	𝑟=0.079	𝑟=0.385	𝑟=0.558	𝑟=0.603^∗	𝑟=0.770
CD4+CD25+FOXP3+/Th1 cells	𝑟=−0.658^∗	𝑟=−0.441	𝑟=0.361	𝑟=−0.181	𝑟=0.176
T2DM without CHD
CD4+IL-17+ cells	𝑟=0.370^∗	𝑟=−0.122	𝑟=0.261	𝑟=0.175	𝑟=0.318^∗
CD4+CD25+FOXP3+ cells	𝑟=0.175	𝑟=0.077	𝑟=−0.122	𝑟=0.190	𝑟=0.028
CD4+CD25+FOXP3+/Th1 cells	𝑟=−0.317^∗	𝑟=−0.212	𝑟=0.269	𝑟=−0.177	𝑟=−0.072
Healthy control
CD4+IL-17+ cells	𝑟=0.640^∗	𝑟=0.595^∗	𝑟=0.164	𝑟=0.849^∗∗	𝑟=0.652^∗∗
CD4+CD25+FOXP3+ cells	𝑟=0.385	𝑟=−0.007	𝑟=0.453	𝑟=0.698^∗∗	𝑟=0.575^∗
CD4+CD25+FOXP3+/Th1 cells	𝑟=−0.539^∗	𝑟=−0.726^∗∗	𝑟=−0.223	𝑟=−0.139	𝑟=−0.210

∗Significant direct or inverse correlation (𝑃<0.05) and **significant direct or inverse correlation (𝑃<0.01).