Paweł Kleczyński, Jacek Legutko, Tomasz Rakowski, Artur Dziewierz, Zbigniew Siudak, Joanna Zdzienicka, Agata Brzozowska-Czarnek, Andrzej Surdacki, Jacek S. Dubiel, Dariusz Dudek, "Predictive Utility of NT-pro BNP for Infarct Size and Left Ventricle Function after Acute Myocardial Infarction in Long-Term Follow-Up", Disease Markers, vol. 34, Article ID 981968, 6 pages, 2013. https://doi.org/10.3233/DMA-120955
Predictive Utility of NT-pro BNP for Infarct Size and Left Ventricle Function after Acute Myocardial Infarction in Long-Term Follow-Up
PURPOSE: The aim of the study was to evaluate the utility of N-terminal pro-B-type natriuretic peptide (NT-pro BNP, pg/ml) assessment to predict infarct size and left ventricle function after ST-segment elevation myocardial infarction (STEMI) at long-term follow-up.METHODS: In 45 patients with first STEMI less than 3 hours from symptom onset treated with mechanical reperfusion NT-pro BNP was assessed early (at admission) and at 6 months. Cardiac magnetic resonance (CMR) parameters (delayed enhancement infarct size (IS, %), left ventricular end-diastolic (LVEDVI, ml/m2) and end-systolic (LVESVI, ml/m2) volume indexes) were assessed at 6 months.RESULTS: No significant correlation was found between baseline NT-pro BNP assessment and IS and left ventricle function after 6 months. There was a significant correlation between 6-month NT-pro BNP and IS (r = 0.65, p < 0.001) and left ventricle remodeling at 6 months (LVEDVI, r = 0.53, p = 0.001; LVESVI, r = 0.51, p = 0.002).CONCLUSIONS: Assessment of NT-pro BNP level 6 months after STEMI remains a good indicator of infarct size and left ventricle function at long-term follow-up.
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