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Disease Markers
Volume 34, Issue 3, Pages 199-204
http://dx.doi.org/10.3233/DMA-120955

Predictive Utility of NT-pro BNP for Infarct Size and Left Ventricle Function after Acute Myocardial Infarction in Long-Term Follow-Up

Paweł Kleczyński,1 Jacek Legutko,1 Tomasz Rakowski,1 Artur Dziewierz,1 Zbigniew Siudak,1 Joanna Zdzienicka,1 Agata Brzozowska-Czarnek,2 Andrzej Surdacki,1 Jacek S. Dubiel,1 and Dariusz Dudek3

1Department of Cardiology, Jagiellonian University Medical College, Krakow, Poland
2Department of Radiology, Jagiellonian University Medical College, Krakow, Poland
3Department of Interventional Cardiology, Jagiellonian University Medical College, Krakow, Poland

Received 28 December 2012; Accepted 28 December 2012

Copyright © 2013 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

PURPOSE: The aim of the study was to evaluate the utility of N-terminal pro-B-type natriuretic peptide (NT-pro BNP, pg/ml) assessment to predict infarct size and left ventricle function after ST-segment elevation myocardial infarction (STEMI) at long-term follow-up.

METHODS: In 45 patients with first STEMI less than 3 hours from symptom onset treated with mechanical reperfusion NT-pro BNP was assessed early (at admission) and at 6 months. Cardiac magnetic resonance (CMR) parameters (delayed enhancement infarct size (IS, %), left ventricular end-diastolic (LVEDVI, ml/m2) and end-systolic (LVESVI, ml/m2) volume indexes) were assessed at 6 months.

RESULTS: No significant correlation was found between baseline NT-pro BNP assessment and IS and left ventricle function after 6 months. There was a significant correlation between 6-month NT-pro BNP and IS (r = 0.65, p < 0.001) and left ventricle remodeling at 6 months (LVEDVI, r = 0.53, p = 0.001; LVESVI, r = 0.51, p = 0.002).

CONCLUSIONS: Assessment of NT-pro BNP level 6 months after STEMI remains a good indicator of infarct size and left ventricle function at long-term follow-up.