Disease Markers / 2013 / Article / Tab 5

Research Article

Association between −308 G/A TNF-α Polymorphism and Appendicular Skeletal Muscle Mass Index as a Marker of Sarcopenia in Normal Weight Obese Syndrome

Table 5

Biochemical parameters in study groups in accordance with the genotype of the G/A polymorphism at positions −308 of the TNF-α gene promoter.

ParametersNW . 17NWO . 30Preobese . 48
All
( . 17)
Carrier (−)
( . 13)
Carrier (+)
( . 4)
All
( . 30)
Carrier (−)
( . 22)
Carrier (+)
( . 8)
All
( . 48)
Carrier (−)
( . 35)
Carrier (+)
( . 13)

FG (mg/dL)91,92 ± 4,4492,22 ± 3,8791,25 ± 6,1890,42 ± 6,7590,69 ± 7,1289,83 ± 6,4690,76 ± 8,3291,34 ± 8,3489,14 ± 8,97
FI ( U/mL)6,47 ± 4,616,60 ± 4,986,13 ± 4,426,35 ± 3,505,58 ± 2,617,88 ± 4,819,71 ± 4,57nc9,83 ± 4,72ef9,24 ± 4,38
HOMA-IR2,70 ± 2,022,75 ± 2,192,58 ± 1,912,62 ± 1,542,32 ± 1,153,22 ± 2,154,03 ± 1,96nc4,14 ± 2,11er3,58 ± 1,33
TC (mg/dL)182,92 ± 38,62183,33 ± 45,76182,00 ± 19,51191,50 ± 30,57196,29 ± 29,04180,33 ± 33,82210,74 ± 42,06n213,85 ± 43,49e208,00 ± 32,85
HDL (mg/dL)70,92 ± 11,6472,44 ± 11,6667,50 ± 12,5069,70 ± 15,6068,21 ± 15,7673,17 ± 16,0860,62 ± 15,11b61,15 ± 15,99e58,57 ± 11,86
LDL (mg/dL)97,58 ± 34,5396,22 ± 38,34101,67 ± 25,40104,11 ± 26,73109,38 ± 26,2292,67 ± 26,33129,21 ± 34,64no128,36 ± 36,04e132,33 ± 31,78
TG (mg/dL)74,77 ± 27,0372,78 ± 24,1679,25 ± 36,4390,00 ± 34,5394,00 ± 39,7880,67 ± 16,33101,97 ± 41,83n105,00 ± 41,64e97,00 ± 44,29
TC/HDL ratio2,60 ± 0,482,54 ± 0,482,76 ± 0,522,84 ± 0,643,00 ± 0,692,49 ± 0,313,63 ± 0,81bc3,63 ± 0,83r3,64 ± 0,77u
TC/LDL ratio1,36 ± 0,471,33 ± 0,481,44 ± 0,511,47 ± 0,681,55 ± 0,781,28 ± 0,352,07 ± 0,80bco2,02 ± 0,81er2,27 ± 0,80u
LDL/HDL1,98 ± 0,332,01 ± 0,361,88 ± 0,281,90 ± 0,281,86 ± 0,262,01 ± 0,301,75 ± 0,44b1,77 ± 0,481,66 ± 0,26u
Log TG/HDL ratio1,09 ± 0,511,02 ± 0,341,26 ± 0,831,34 ± 0,571,43 ± 0,641,14 ± 0,341,80 ± 0,88bo1,85 ± 0,95e1,63 ± 0,56
hs-CRP ( g/dL)0,10 ± 0,170,12 ± 0,200,04 ± 0,060,40 ± 0,850,57 ± 1,010,06 ± 0,090,94 ± 2,11bo1,06 ± 2,32e0,44 ± 0,78
TNF-α (pg/mL)27,51 ± 19,7730,50 ± 22,2518,53 ± 2,7823,55 ± 11,4723,01 ± 10,6424,90 ± 14,3723,11 ± 15,2125,55 ± 15,5810,91 ± 1,29x

Carrier (−): G/G −308 TNF-α genotype; carrier (+): G/A −308 TNF-α genotype; FG: fasting glucose; FI: fasting insulin; HOMA-IR: homeostasis model of assessment-insulin resistance; TC: total cholesterol; HDL-chol: HDL cholesterol; LDL-chol: LDL cholesterol; TG: triglycerides; hs-CRP: high-sensitivity C-reactive protein.
NW all versus NWO all; NW all versus Preob-Ob all; NWO all versus Preob-Ob all; NW carrier (−) versus NWO carrier (−); NW carrier (−) versus Preob-Ob carrier (−); NWO carrier (−) versus Preob-Ob carrier (−); NW carrier (+) versus NWO carrier (+); NW carrier (+) versus Preob-Ob carrier (+); NWO carrier (+) versus Preob-Ob carrier (+); NW carrier (−) versus NW carrier (+); NWO carrier (−) versus NWO carrier (+); Preob-Ob carrier (−) versus Preob-Ob carrier (+); NW all versus NWO all; NW all versus Preob-Ob all; NWO all versus Preob-Ob all; NW carrier (−) versus NWO carrier (−); NW carrier (−) versus Preob-Ob carrier (−); NWO carrier (−) versus Preob-Ob carrier (−); NW carrier (+) versus NWO carrier (+); NW carrier (+) versus Preob-Ob carrier (+); NWO carrier (+) versus Preob-Ob carrier (+); NW carrier (−) versus NW carrier (+); NWO carrier (−) versus NWO carrier (+); Preob-Ob carrier (−) versus Preob-Ob carrier (+).

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