Increased LEF1 Expression and Decreased Notch2 Expression Are Strong Predictors of Poor Outcomes in Colorectal Cancer Patients

Figure 1

Immunohistochemical expression of LEF1 and Notch2 in CRC and paratumorous normal colorectal tissues. (a) Immunohistochemical staining of LEF1 expression in paratumorous normal colorectal tissues (A1) and CRC tissues (A2–A4), (A1) negative expression (score 0), (A2) weak expression (score 1–4), (A3) moderate expression (score 5–8), and (A4) strong expression (score 9–12). (b) Immunohistochemical staining of Notch2 expression in paratumorous normal colorectal tissues (B1) and CRC tissues (B2–B4), (B1) strong expression (score 9–12), (B2) negative expression (score 0), (B3) weak expression (score 1–4), and (B4) moderate expression (score 5–8); scale bars, 25 μm.

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