Increased LEF1 Expression and Decreased Notch2 Expression Are Strong Predictors of Poor Outcomes in Colorectal Cancer Patients

Table 1

Results of LEF1 and Notch2 immunohistochemical analysis in tumor tissue in relation to the clinicopathologic characteristics of CRC patients and their tumors.

Characteristic	n	LEF1 expression		P	Notch2 expression		P
		Low	High		Low	High
Total	184	58	126		120	64
Age (years)				0.330			0.634
<60	72	26	46		45	27
≥60	112	32	80		75	37
Gender				0.339			0.640
Male	104	36	68		66	38
Female	80	22	58		54	26
Tumor location				0.858			0.200
Right colon	40	12	28		30	10
Left colon	46	16	30		26	20
Rectum	98	30	68		64	34
Histology (differentiation)				0.071			<0.001
Well	86	24	62		42	44
Moderate	68	28	40		56	12
Poor	30	6	24		22	8
Node metastasis				0.001			<0.001
𝑁0	80	36	44		68	12
𝑁1--3	104	22	82		52	52
Distant metastasis				<0.001			<0.001
No	144	56	88		84	60
Yes	40	2	38		36	4
TNM stage				<0.001			<0.001
I	14	6	8		4	10
II	56	12	44		40	16
III	74	36	38		42	32
IV	40	4	36		34	6