Increased LEF1 Expression and Decreased Notch2 Expression Are Strong Predictors of Poor Outcomes in Colorectal Cancer Patients

Table 2

Results of LEF1 and Notch2 mRNA real-time PCR analysis in tumor tissue in relation to the clinicopathologic characteristics of CRC patients and their tumors.

Characteristic	n	LEF1, mean (SD)	P	Notch2, mean (SD)	P
Tissue type			<0.001		<0.001
CRC tissues	184	3.7270 (1.7635)		0.5263 (0.3320)
Paratumorous normal tissues	184	0.8239 (0.2624)		1.8675 (0.4230)
Age (years)			0.245		0.292
<60	72	3.6175 (1.5221)		0.5613 (0.4012)
≥60	112	3.8617 (1.1551)		0.5038 (0.2875)
Gender			0.879		0.712
Male	104	3.7410 (1.6041)		0.5241 (0.4057)
Female	80	3.7088 (1.2707)		0.5417 (0.2362)
Tumor location			0.611		0.365
Right colon	40	3.6889 (1.3662)		0.5579 (0.2331)
Left colon	46	3.5371 (1.4057)		0.5784 (0.4124)
Rectum	98	3.8317 (1.8993)		0.4992 (0.3346)
Histology (differentiation)			0.609		<0.001
Well	86	3.6022 (1.9496)		0.6760 (0.4661)
Moderate	68	3.7840 (1.6342)		0.4514 (0.2112)
Poor	30	3.9557 (1.5231)		0.3002 (0.2214)
Node metastasis			<0.001		<0.001
𝑁0	80	2.2058 (1.7023)		0.6510 (0.4138)
𝑁1--3	104	4.8971 (1.8106)		0.4304 (0.2691)
Distant metastasis			<0.001		<0.001
No	144	3.1840 (1.7412)		0.6084 (0.1059)
Yes	40	5.6818 (1.8334)		0.2557 (0.5460)
TNM stage			<0.001		<0.001
I	14	2.1012 (1.7731)		0.8526 (0.2113)
II	56	2.9875 (1.2111)		0.6752 (0.2547)
III	74	3.3415 (1.8521)		0.4369 (0.1821)
IV	40	6.0445 (1.9694)		0.3940 (0.6921)