Increased LEF1 Expression and Decreased Notch2 Expression Are Strong Predictors of Poor Outcomes in Colorectal Cancer Patients
Table 3
Association of LEF1/Notch2 and clinical factors with overall survival.
Clinicopathologic characteristics
n
Risk ratioa (95% CI)
P
Risk ratiob (95% CI)
P
LEF1
Low
58
—
—
High
126
2.31 (1.15–4.64)
0.016
2.67 (1.31–4.85)
<0.001
Notch2
High
64
—
—
Low
120
2.26 (1.15–4.43)
0.017
2.48 (1.22–4.80)
<0.001
Age
<60
72
—
—
≥60
112
0.44 (0.23–0.87)
0.698
0.35 (0.12–1.01)
0.053
Gender
Female
104
—
—
Male
80
0.98 (0.55–1.71)
0.909
1.01 (0.97–1.06)
0.532
Tumor location
Right colon
40
—
—
Left colon
46
1.17 (0.59–2.37)
0.644
0.65 (0.13–1.27)
0.604
Rectum
98
0.79 (0.34–1.83)
0.587
0.63 (0.18–1.25)
0.476
Histology (differentiation)
Well
86
—
—
Moderate
68
1.45 (1.20–1.98)
0.001
0.57 (0.19–1.69)
0.313
Poor
30
2.72 (2.11–3.42)
<0.001
0.55 (0.20–1.47)
0.231
TNM stage
I
14
—
—
II
56
1.32 (0.29–6.14)
0.719
1.19 (0.72–1.72)
0.256
III
74
2.88 (1.06–7.28)
0.038
2.85 (1.13–7.44)
0.030
IV
40
2.76 (1.38–5.51)
0.004
2.83 (1.68–4.74)
<0.001
LEF1 and Notch2
Other combinations
89
—
—
LEF1 (H)/Notch2 (L)
95
3.40 (1.90–7.25)
0.006
2.66 (1.98–3.32)
<0.001
aUnadjusted risk ratio in univariate models.
bAdjusted risk ratio in multivariate models. CI: confidence interval. L: low expression; H: high expression.
