Association of Polymorphisms of Genes Involved in Lipid Metabolism with Blood Pressure and Lipid Values in Mexican Hypertensive Individuals
Table 3
Results of ANOVA, Student’s , and correlation tests between polymorphisms and quantitative variables in normolipemic and hyperlipemic hypertensive patients.
APOA5 p.S19W
Variable
Genotype SS
Genotype WW
Subgroup
ANOVA
HDL-C (mg/dL)
41.6
67.0
0.000
Normolipemic
HDL-C (mg/dL)
49.5SW
67.0
0.001
Normolipemic
TG (mg/dL)
172.0
221.0
0.032
Hyperlipemic
Allele S
Allele W
P
Correlation
P
Student’s -test
HDL-C (mg/dL)
43.6
52.3
0.007
0.361
0.010
TG (mg/dL)
183.5
235.5
0.023
0.315
0.048
APOB p.E4181K
Variable
Genotype EE
Genotype EK
P
Subgroups
ANOVA
TG (mg/dL)
121.6
88.3
0.006
Normolipemic
Allele E
Allele K
Correlation
P
Student’s -test
TG (mg/dL)
114.6
83.2
0.003
−0.435
0.002
FABP2 p.A55T
Variable
Genotype AA
Genotype TT
P
Subgroups
ANOVA
LDL-C
170.2
135.9
0.018
Hyperlipemic
TG (mg/dL)
164.3
237.2
0.090a
Hyperlipemic
SBP (mm Hg)
145.0
156.0
0.082a
Normolipemic
Allele A
Allele T
P
Correlation
P
Student’s -test
LDL-C
162.2
141.5
0.018
−0.328
0.042
TG (mg/dL)
169.2
216.5
0.006
0.382
0.017
SBP (mm Hg)
147.1
155.0
0.007
0.346
0.026
LPL p.S474X
Variable
Genotype SS
Genotype SX
P
Subgroups
ANOVA
TC (mg/dL)
236.0
189.4
0.035
Hyperlipemic
Allele S
Allele X
P
Correlation
P
Student’s -test
TC (mg/dL)
234.1
189.6
0.039
−0.335
0.035
MTTP −493 G>T
Variable
Genotype GG
Genotype GT
P
Subgroups
ANOVA
SBP (mm Hg)
141.5
154.5
0.023
Hyperlipemic
Allele G
Allele T
P
Correlation
P
Student’s -test
SBP (mm Hg)
144.2
154.5
0.003
0.364
0.023
TG: triglycerides; TC: total cholesterol; SBP: systolic blood pressure; aNonsignificant P value, but significant in the remaining statistical tests.
