miR-146a Expression Level as a Novel Putative Prognostic Marker for Acute Promyelocytic Leukemia

Figure 1

The functional role of miR-146a. (a) Forced expression of miR-146a by transfection of cells with pre-miR-146a with lipidosome significantly inhibited apoptosis, whereas downregulation of miR-146a by anti-pre-miR miR-146a inhibitor significantly increased apoptosis in NB₄ cells. (b) Forced expression of miR-146a significantly increased, whereas downregulation of miR-146a significantly decreased cell proliferation in NB₄ cells. (c) The cell cycle was not affected after ectopic expression of miR-146a. Normalized mean values of 3 independent experiments and standard errors (means ± SDs) are shown. ∗, 𝑃≤0.05; ∗∗, 𝑃≤0.001 (paired 𝑡 test).

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