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Disease Markers
Volume 2014, Article ID 162517, 5 pages
Research Article

Serum Omentin-1 as a Disease Activity Marker for Crohn’s Disease

1Department of Gastroenterology, Liaocheng People’s Hospital, Liaocheng 252000, China
2Department of Pathology, Liaocheng Second People’s Hospital, Linqing 252600, China
3Department of Radiology, Binzhou Medical College Hospital, Binzhou 256603, China
4Department of Pharmacy, Liaocheng International Peace Hospital, Liaocheng 252000, China
5Central Laboratory, Liaocheng People’s Hospital, Liaocheng 252000, China
6Department of Pathology, Liaocheng People’s Hospital, Liaocheng 252000, China

Received 24 November 2013; Accepted 31 December 2013; Published 11 February 2014

Academic Editor: Yi-Chia Huang

Copyright © 2014 Yan Lu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background and Aim. It remains challenging to determine the inflammatory activity in Crohn’s disease (CD) for lack of specific laboratory markers. Recent studies suggest that serum omentin-1 is associated with inflammatory response. We aimed to assess the potential of serum omentin-1 as a marker of disease activity in CD patients. Methods. Serum omentin-1 concentrations were determined by enzyme-linked immunosorbent assay (ELISA) in patients with CD (), functional gastrointestinal disorders (FGDs, ), and healthy controls (HC, ) and evaluated for correlation with disease activity. Expression of omentin-1 in colonic tissues from patients with CD was also analyzed by real-time PCR and Western blotting. Serum omentin-1 levels as an activity index were evaluated using a receiver operating characteristic (ROC) curve. Results. Serum omentin-1 concentrations were significantly decreased in active CD patients compared with patients in remission, FGDs, and HC (all ). Expression of omentin-1 was decreased at mRNA and protein levels in inflamed colonic tissues in active CD than that in noninflamed colonic tissues. Serum omentin-1 levels were negatively correlated with disease activity in CD, better than C-reactive protein (CRP). Conclusion. Our results indicate that serum and colonic omentin-1 expressions are decreased in active CD patients. The correlation of serum omentin-1 with disease activity in CD is superior to that of CRP. Serum omentin-1 is a potential marker for CD disease activity.