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Disease Markers
Volume 2014, Article ID 168960, 7 pages
Research Article

Serum Clusterin as a Tumor Marker and Prognostic Factor for Patients with Esophageal Cancer

1Department of Thoracic Surgery, Fudan University Shanghai Cancer Center (FUSCC), Shanghai 200032, China
2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
3Department of Radiation Oncology, Kimmel Cancer Center and Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA
4Department of Biostatistics, Public Health School, Fudan University, Shanghai 200032, China
5Department of Pathology, Fudan University Shanghai Cancer Center (FUSCC), Shanghai 200032, China
6Department of Thoracic Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin 2nd Road, Shanghai 200025, China

Received 21 September 2014; Revised 24 November 2014; Accepted 25 November 2014; Published 10 December 2014

Academic Editor: Yi-Chia Huang

Copyright © 2014 Wei Guo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Recent studies have revealed that clusterin is implicated in many physiological and pathological processes, including tumorigenesis. However, the relationship between serum clusterin expression and esophageal squamous cell carcinoma (ESCC) is unclear. Methods. The serum clusterin concentrations of 87 ESCC patients and 136 healthy individuals were examined. An independent-samples Mann-Whitney test was used to compare serum clusterin concentrations of ESCC patients to those of healthy controls. Univariate analysis was conducted using the log-rank test and multivariate analyses were performed using the Cox proportional hazards model. Results. In healthy controls, the mean clusterin concentration was μg/mL, while in the ESCC patients, the mean clusterin concentration was higher at μg/mL (). The 1-, 2-, and 4-year survival rates for the 87 ESCC patients were 89.70%, 80.00%, and 54.50%. Serum clusterin had an optimal diagnostic cut-off point (serum clusterin concentration = 335.5 μg/mL) for esophageal squamous cell carcinoma with sensitivity of 71.26% and specificity of 77.94%. And higher serum clusterin concentration (>500 μg/mL) indicated better prognosis (). Conclusions. Clusterin may play a key role during tumorigenesis and tumor progression of ESCC and it could be applied in clinical work as a tumor marker and prognostic factor.